Glioblastoma Multiforme

Mar 1, 2017 by in HEMATOLOGY Comments Off on Glioblastoma Multiforme

Glioblastoma multiforme is the most common primary malignant tumor of the central nervous system. Despite new insights into glioblastoma pathophysiology, the prognosis for patients diagnosed with this highly aggressive tumor remains…

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Anaplastic Gliomas

Mar 1, 2017 by in HEMATOLOGY Comments Off on Anaplastic Gliomas

The optimal treatment of anaplastic gliomas is controversial. Options for treatment include radiation, chemotherapy or a combination of modalities. This article describes how treatment algorithms for anaplastic gliomas have evolved…

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Complications of Brain Tumors and Their Treatment

Mar 1, 2017 by in HEMATOLOGY Comments Off on Complications of Brain Tumors and Their Treatment

The diverse medical and neurologic complications of central nervous system (CNS) neoplasms or their treatment cause significant morbidity and mortality. Thus, their recognition and appropriate management by all members of…

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Overview of Primary Brain Tumors

Mar 1, 2017 by in HEMATOLOGY Comments Off on Overview of Primary Brain Tumors

Contemporary neuropathology plays a key role in the multidisciplinary management of brain tumor patients, in part due to increased supplementation of histopathological assessments by molecular diagnostic tests involving brain tumor…

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Central Nervous System Malignancies

Mar 1, 2017 by in HEMATOLOGY Comments Off on Central Nervous System Malignancies

Jill Lacy, MD, Guest Editor Related posts: Glioblastoma Multiforme Clinical Manifestations and Diagnostic Imaging of Brain Tumors Management of Brain Metastases Role of Neurosurgery and Radiation Therapy in the Management…

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Systemic Mastocytosis

Mar 1, 2017 by in HEMATOLOGY Comments Off on Systemic Mastocytosis

The clinical presentation of mastocytosis is diverse, and patients may not fit the classical description. Diagnosis requires a bone marrow examination, including immunohistochemical stains for mast cell tryptase or CD117….

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Clinical Predictors of Outcome in MPN

Mar 1, 2017 by in HEMATOLOGY Comments Off on Clinical Predictors of Outcome in MPN

Myeloproliferative neoplasms include 3 diseases: polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). PV and ET are dominated by a high risk of thrombosis and a late risk…

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Role of Germline Genetic Factors in MPN Pathogenesis

Mar 1, 2017 by in HEMATOLOGY Comments Off on Role of Germline Genetic Factors in MPN Pathogenesis

It is thought that myeloproliferative neoplasms (MPNs) are driven by somatic mutations, although hereditary factors also play a prominent role in the pathogenesis of the disease. Hereditary thrombocytosis and erythrocytosis…

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Myeloproliferative Neoplasm Animal Models

Mar 1, 2017 by in HEMATOLOGY Comments Off on Myeloproliferative Neoplasm Animal Models

Myeloproliferative neoplasm (MPN) animal models accurately re-capitulate human disease in mice and have been an important tool for the study of MPN biology and therapy. Transplantation of BCR-ABL transduced bone…

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