Epigenetics of Thyroid Cancer
Fig. 15.1 RASSF1 chromosome location (The red line on the p arm) Buffy coat sample analysis also displayed an increased promoter hypermethylation of RASSF1A in children with thyroid carcinoma (Wong…
LINE-1 Retrotransposons and Their Role in Cancer
Fig. 3.1 Classes of interspersed repeats with their examples. (termini of the branches, and their taxa of origin in square brackets). For each class their copy number and contribution (%)…
Reciprocal Interconnection of miRNome-Epigenome in Cancer Pathogenesis and Its Therapeutic Potential
Epigenetically regulated miRNAs Location Cancer type Target protein References miR-1–1 & -2 20q13.33 (miR-1-1) 18q11.2 (miR-1-2) Hepatocellular carcinoma FOXP1 MET HDAC4 (Datta et al. 2008) Let-7i 12q14.1 Cholangiocytes TLR4 (O’Hara et al….
Essence of Cancer Epigenetic: A Harmonic Art for the Future
Fig. 17.1 The map of cancer development . (Adopted from P. Mehdipour’s archive) Epigenetic as the result of genes/environmental interaction, through embryonic at the right time and precise direction and…
Biodynamic Phenotypic and Epigenetics Changes of Circulating Tumor Cells: Their Application in Cancer Prognosis and Treatment
Fig. 2.1 Dissemination tumor process. Metastasis process involves the relapse of tumor cells from primary tumor to target organ. This metastasis process is dependent to survival capacity of different subpopulation…
An Introduction to Impact of Bio-Resonance Technology in Genetics and Epigenetics
Fig. 16.1 Schematic diagrams of Bioresonance therapy Bioresonance therapy (BRT) is based upon the knowledge that the entire body is held together at the subatomic level by waves and photons….
Reduced Risk of Cancer in Schizophrenia, a Bridge Toward Etio-Pathology and Therapy of Both Diseases
Fig. 5.1 TGF-β signaling prevents cancer development, but promote carcinogenesis and angiogenesis in advanced carcinomas. TGF-β regulates immune system by the mediation of FOXP3, which is over-expressed in tumor cells…
Predictive Role of O6-Methylguanine DNA Methyltransferase Status for the Treatment of Brain Tumors
Study Number of patients Treatment Assay MGMT status (frequency, %) Survival p PFS OS PFS OS Newly diagnosed glioblastoma Jaeckle et al. 1998 40 SR-RT-BCNU Protein expression: quantative immunofluorescence Low level:…
Epigenetics and Three Main Clinical Aspects of Breast Cancer Management
Study Year Study population Method Main Result 1-(Snell et al. 2008) 2008 Familial breast cancer without BRCA1or BRCA2 mutations MethyLight, MS-HRM (Methylation specific high resolution melting) Hypermethylation of BRCA1 in tumors,…
Retinoic Acid Receptor-β, From Gene to Clinic
Species Chromosomal location Gene symbol Size Other symbols Human 3p24.2 RARB 423 kb HAP, RRB2, NR1B2, MCOPS12 Mouse 14 A1-A3; 14 7.08 cM Rarb 164 kb Hap, Nr1b2, RARbeta2, A830025K23…
