General Overview and Incidence Pediatric hematology/hematopathology spans the spectrum of benign, malignant, and neoplastic mimickers. Neoplastic lymphoid, myeloid, and histocytic neoplasms follow criteria in the updated World Health Organization (WHO)…
General Overview and Incidence Incidence varies depending on the institution, patient population, allograph types, and immunosuppression regimes. Etiology/Histopathology Clinical settings causing immune dysfunctions, such as viral Epstein-Barr virus (EBV) infection,…
General Overview and Incidence Overview of Hemophilia The hemophilias are bleeding disorders caused by the absence or decrease of factor VIII in hemophilia A or factor IX in hemophilia B….
General Overview and Incidence Multiple myeloma (MM) is a malignancy of clonal plasma cells and is part of a spectrum of plasma cells disorders encompassing the benign asymptomatic condition monoclonal…
General Overview and Incidence Precursor lymphoid neoplasms or acute lymphoblastic leukemia (ALL) is the second most common leukemia affecting adults with about 1.6 per 100,000 and 6500 cases per year…
General Overview Myelodysplastic syndromes (MDSs) represent a heterogeneous group of myeloid neoplasms characterized by abnormal differentiation and maturation of myeloid cells, ineffective hematopoiesis, and increased risk of transformation to acute…
General Overview and Incidence • Definition of Hodgkin lymphoma (HL): lymphoid neoplasm affecting lymph nodes; paucity of neoplastic cells with rich inflammatory background • Classic Hodgkin lymphoma (cHL) 90% to…
A Brief Overview of Acute Myeloid Leukemia Acute myeloid leukemia (AML) is understood to be the product of genetic and epigenetic changes within a multipotent myeloid stem/progenitor cell that generate…
General Overview and Incidence Mastocytosis is no longer under the broad category of myeloproliferative neoplasm (MPN). Mastocytosis is a heterogeneous disease of clonal neoplastic proliferation and expansions of mast cells…
General Overview Myeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized by abnormal chronic proliferation of cells belonging to myeloid lineages that are often associated with elevated blood counts, splenomegaly,…
