Central Hypothyroidism

Jul 14, 2017 by in ENDOCRINOLOGY Comments Off on Central Hypothyroidism

Main causes Inheritable defects CPHDs  Pituitary transcription factor defects  LEPR or PROKR2 mutations Isolated CH  TSHβ, TRHR or IGSF1 mutations Invasive or compressive lesions Craniopharyngiomas Pituitary macroadenomas Meningiomas or gliomas…

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Subclinical Hypothyroidism

Jul 14, 2017 by in ENDOCRINOLOGY Comments Off on Subclinical Hypothyroidism

Thyroid-related causes Systemic causes Hashimoto’s thyroiditis Diabetes mellitus Iodine deficiency Celiac disease Overtreatment of Graves’ disease Chronic renal failure Transient neonatal hyperthyrotropinemia Syndromes (Turner, Down …) Variations in genes of…

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Thyroid Embryogenesis

Jul 14, 2017 by in ENDOCRINOLOGY Comments Off on Thyroid Embryogenesis

Fig. 1.1 Early stage of mammalian development. Panel a: Schematic cross-section of a mammalian embryo after gastrulation. The position of three germ layers, ectoderm (brown), mesoderm (orange), and endoderm (green)…

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Autoimmune Thyroiditis

Jul 14, 2017 by in ENDOCRINOLOGY Comments Off on Autoimmune Thyroiditis

Constitutional and environmental factors Clinical factors Female sex Antecedents of Graves’ disease Adolescent age Association with extra-thyroidal autoimmune diseases Familiarity for thyroid diseases  Iodine status alterations Association with Turner syndrome…

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Etiology of Congenital Hypothyroidism

Jul 14, 2017 by in ENDOCRINOLOGY Comments Off on Etiology of Congenital Hypothyroidism

CH etiology Associated mutations TSH T3 and T4 A. Primary CH Thyroid dysgenesis PAX8 high low TTF2   NKX2.1   NKX2.5   Thyroid dyshormonogenesis NIS/SLC5A5 high low TPO   DUOX2, DUOXA2   Tg   DEHAL1/SECISBP2   SLC26A4  …

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Transient Neonatal Hypothyroidism

Jul 14, 2017 by in ENDOCRINOLOGY Comments Off on Transient Neonatal Hypothyroidism

20. The American Thyroid Association Taskforce on Thyroid Disease During Pregnancy and Ostpartum, Stagnaro-Green A, Abalovich M, Alexander E, et al (2011) Guidelines of the American Thyroid Association for the…

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