Cancer Proteomics
Estimated new cases Estimated deaths Both genders Male Female Both genders Male Female All sites 1,665,540 855,220 810,320 585,720 310,010 275,710 Oral cavity and pharynx 42,440 30,220 12,220 8390…
Personalized Medicine for the Treatment of Human Cancer
Fig. 43.1 Immunohistochemical staining for the estrogen receptor (ER) in breast cancer. The ER is detected as a brown color in the nucleus of the tumor cells (arrows). Fig. 43.2…
Retinoblastoma: Clinical and Molecular Perspectives
Fig. 23.1 Clinical appearance of retinoblastoma. A large retinoblastoma before (left) and after (right) chemotherapy. Note the marked reduction in tumor size after chemotherapy. This view was obtained with a…
An Overview of Cancer Genes
Mutation Description Missense A change in one DNA base pair that results in the substitution of one amino acid Nonsense A change in one DNA base pair that results in…
Molecular Pathology of Bone and Soft Tissue Tumors
Tumor type Cytogenetic finding Molecular trace Reference Ewing sarcoma t(11;22)(q24;q12) EWSR1-FLI1 Delattre et al. [100] t(21;22)(q22;q12) EWSR1-ERG Sorensen et al. [240] t(19;der(ins.inv(21;22))) EWSR1-ERG Maire et al. [241] t(16;21) (p11;q22) FUS-ERGa…
Ovarian Cancer
Name Frequency (%) Morphological features of well differentiated lesions Segment of the reproductive tract with similar features Serous 50 Columnar cells with a prominent ciliated border that often form finger-like…
The Molecular Pathology of Head and Neck Squamous Cell Carcinoma
Fig. 32.1 The histology of conventional and HPV-associated head and neck squamous cell carcinomas (HNSCC). (a) A well differentiated conventional type HNSCC with keratinization (hematoxylin-eosin, 100×). (b) HPV-associated HNSCC which…
Hereditary Colorectal Cancer
White African Americans Asian American and Pacific Islander American Indian and Alaska Native Hispanic/Latino (a) Incidence Males 58.2 68.4 44.1 38.1 50 Females 42.6 51.7 33.1 30.7 35.1 (b)…
Erionite and Asbestos in the Pathogenesis of Human Malignant Mesotheliomas
Fig. 18.1 Scanning electron microscopy (SEM) micrographs showing the morphology of erionite fibers, crocidolite asbestos, and chrysotile fibers. (a) Erionite f ibers from Pine Valley, NV (courtesy of Dr. Ian…
Chromosomes and Chromosomal Instability in Human Cancer
Diagnosis Cytogenetic change Molecular change Additional changes Chronic myeloid leukemia t(9;22)(q34;q11) 210KD BCR-ABL CML-AP/BP t(9;22)(q34;q11) 210KD BCR-ABL +8, +Ph, +19, i(17q), t(3;21)(q26;q22) Polycythemia vera JAK2V617F (>90%) +8, +9, del(20q),…
