Molecular Basis of Prostate Cancer

Feb 15, 2017 by in ONCOLOGY Comments Off on Molecular Basis of Prostate Cancer

Figure 38-1 Examples of Gleason grade 3, 4, and 5 prostate cancer. Gleason grade 3 shows well-formed, separate glands (A). Gleason grade 4 shows merging or cribriform glands (B). Gleason…

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Genetic Mouse Models of Cancer

Feb 15, 2017 by in ONCOLOGY Comments Off on Genetic Mouse Models of Cancer

Figure 9-1 Non–genetically engineered mouse models of cancer (A,B) Mice develop tumors spontaneously or in response to carcinogen exposure. (C,D) Transplantation of human or mouse tumor cells into recipient mice…

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The Biology of Primary Brain Tumors

Feb 15, 2017 by in ONCOLOGY Comments Off on The Biology of Primary Brain Tumors

Molecular Biology of the Most Common Primary Central Nervous System Tumors Brain tumors are thought to arise as the result of genetic and epigenetic alterations that activate oncogenes and inactivate…

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Molecular Pathogenesis of Pancreatic Adenocarcinoma

Feb 15, 2017 by in ONCOLOGY Comments Off on Molecular Pathogenesis of Pancreatic Adenocarcinoma

Figure 35-1 Pancreatic epithelial neoplasia and the multistep model of exocrine pancreatic cancer. (From Maitra A, Adsay NV, Argani P, et al. Multicomponent analysis of the pancreatic adenocarcinoma progression model…

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Animal Models

Feb 15, 2017 by in ONCOLOGY Comments Off on Animal Models

Figure 8-1 Model organisms (the budding yeast—Saccharomyces cerevisiae; the fruit fly—Drosophila melanogaster; and the zebrafish—Danio rerio) and their key attributes as models for dissecting the molecular basis of cancer. Forward…

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Cancer Chemoprevention

Feb 15, 2017 by in ONCOLOGY Comments Off on Cancer Chemoprevention

5-LOX, 5-Lipoxygenase; CDK, cyclin-dependent kinase; DFMO, difluoromethylornithine; EGFR, epidermal growth factor receptor; ER, estrogen receptor; FGFR, fibroblast growth factor receptor; HIF-1α, hypoxia-inducible factor-1 alpha; IGF-1R, insulin-like growth factor-1 receptor; MEK,…

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Soft Tissue Sarcomas

Feb 15, 2017 by in ONCOLOGY Comments Off on Soft Tissue Sarcomas

t(1:13)(p36;q14) PAX3-FOXO1A PAX7-FOXO1A Alveolar soft-part sarcoma t(X;17)(p11;q25) TFE3-ASPL Angiomatoid fibrous histiocytoma t(12;16)(q13;p11) CREB1-EWSR1 ATF1-FUS Clear cell sarcoma t(12;22)(q13;q12) ATF1-EWSR1 CREB1-EWSR1 Dermatofibrosarcoma protuberans t(17;22)(q22;q13) PDGFB- COL1A1 Desmoplastic small round cell tumor…

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Molecular Genetics of Acute Lymphoblastic Leukemia

Feb 15, 2017 by in ONCOLOGY Comments Off on Molecular Genetics of Acute Lymphoblastic Leukemia

Figure 26-1 Kaplan-Meier analysis of overall survival in 2628 children with newly diagnosed acute lymphocytic leukemia (ALL). The patients participated in 15 consecutive studies conducted at St. Jude Children’s Research…

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