OpenPET Enabling PET Imaging During Radiotherapy
Fig. 4.1 Shows the comparison between a conventional PET detector (a) and the depth-of-interaction (DOI) detector (b). The DOI detector eliminates the parallax error, caused by the thickness of the…
Applications of UIH High-Resolution PET/CT in Zhongshan Hospital
Fig. 8.1 Mini Deluxe Phantom tested by UIH PET/CT scanner Fig. 8.2 Hoffman brain phantom tested by UIH PET/CT scanner 8.2 Animal Study Animal studies were applied to focus on…
Optical Imaging: How Far Can We Go
Fig. 7.1 Immunohistochemistry (IHC) of murine testis. (a) Antibody-specific staining of a protein antigen, which is selectively present in male germ cells with maximal levels (dark-brown staining) at spermatogonia-spermatocyte stage,…
Recent Developments with Large-Bore PET/CT
Model name Company Patient port size [mm] PET detector ring FDA cleared PET CT Diameter [mm] [year] ECAT Accel CTI (Siemens) 562 N/A 824 2000 Discovery LS GE Healthcare 600…
Theranostic Approaches for Pathway-Activated Systems in Oncology
Diagram 2.1 Epigenetic dysregulation of the metabolic signaling pathways that control cell growth, survival, and chemoresistance mechanisms in DLBCL. Our previous studies have shown that deregulated NF-kB, NFAT, and STAT3…
PET Radiotracers for Tumor Imaging
Fig. 1.1 [18F]FDG Although PET facilities are rapidly increasing worldwide, the only PET radiopharmaceutical currently available for diagnosis is [18F]FDG. In keeping with this notion, [18F]FDG is by far the…
Clinical Evaluation of Focused High-Resolution Breast PET
Fig. 9.1 Types of dedicated breast PET scanners. (a) Positron emission mammography (PEM). (b) Fully tomographic dedicated breast PET with dual-plate detector rotating around the breast. (c) Fully tomographic dedicated…
Optimization of Aseptic Production in PET Radiopharmaceuticals for Compliance to the Most Current GMP
Grade At rest In operation 0.5 pe 5.5 m 0.5 pe 5.5 A 3520 20 3520 20 B 3520 29 352,000 2900 C 352,000 2900 3,520,000 29,000 D 3,520,000 29,000…
Visualization of Apoptosis: Annexin V Imaging
Imaging system Isotope Radiotracer Applied animal model Reference SPECT 99mTc 99mTc-BTAP-AnnexinV Atrial thrombi {Stratton, 1995 #4} {Narula, 2001 #5} 99mTc-HYNIC-Annexin V Jurkat T-cell lymphoblasts {Blankenberg, 1999 #3} {Blankenberg, 1999 #3}…
Ethics, Regulations, and Clinical Development of Precision Medicine: Activating with Molecular Imaging
Fig. 6.1 Constructions of guidance documents by FDA concerning medical imaging drug development and radioactive drug clinical research 6.3.1.3 Clinical Trial Network and Standardization Accordingly, more and more quality assurance…
