Chapter Outline EPIDEMIOLOGY PRENATAL ORIGIN OF INFANT LEUKEMIA RISK FACTORS BIOLOGY OF MIXED-LINEAGE LEUKEMIA TRANSLOCATIONS ACUTE LYMPHOBLASTIC LEUKEMIA Clinical and Biologic Features Prognostic Factors and Outcomes Treatment ACUTE MYELOID LEUKEMIA…
Chapter Outline THE LYSOSOMAL SYSTEM Morphology and Physiology Biosynthesis and Biogenesis Pathogenesis OVERVIEW OF LYSOSOMAL STORAGE DISEASES AND THEIR DIAGNOSES The Sphingolipidoses The Mucopolysaccharidoses Multiple Sulfatase Deficiency Mucolipidosis Type II/…
Chapter Outline QUANTITATIVE PLATELET ABNORMALITIES Thrombocytopenia Thrombocytosis ACQUIRED DEFECTS IN PLATELET FUNCTION Drug-Induced Platelet Dysfunction Platelet Abnormalities Associated with Systemic Diseases Platelets play a critical role in hemostasis. When the…
Chapter Outline FIBRINOGEN DISORDERS Hypofibrinogenemia and Afibrinogenemia Dysfibrinogenemia PROTHROMBIN DISORDERS Factor V Deficiency Combined Deficiency of Factor V and Factor VIII Factor X Deficiency Factor VII Deficiency Factor XI Deficiency…
Chapter Outline COMBINED IMMUNODEFICIENCIES Severe Combined Immunodeficiency Other Forms of Combined Immunodeficiency with Variable Presentation MANAGEMENT OF COMBINED IMMUNODEFICIENCY Diagnostic Approach Hematopoietic Stem Cell Transplantation Gene Therapy IMMUNODEFICIENCY SYNDROMES Wiskott-Aldrich…
Chapter Outline PRINCIPLES OF CANCER PREDISPOSITION IDENTIFICATION OF A CHILD WITH A CONDITION PREDISPOSING TO CANCER Features of Family History Suggestive of a Heritable Predisposition to Cancer Tumor Features Suggestive…
Chapter Outline FUNCTIONAL GENETICS OF CHILDHOOD CANCER PREDISPOSITION SYNDROMES DYSREGULATION OF CELL DIVISION AND GROWTH DNA REPAIR AND GENOME INSTABILITY ABERRANT GENE EXPRESSION SOMATICALLY ACQUIRED GENE MUTATIONS AND CANCER GENOMICS…
Chapter Outline DESCRIPTIVE EPIDEMIOLOGY International Patterns Age-Specific Incidence and Sex Ratio Ethnic Origin Socioeconomic Status Time Trends Clustering of Leukemia in Space and Time GENETIC FACTORS AND FAMILIAL AGGREGATION Concordance…
Chapter Outline MEMBRANE LIPIDS Lipid Composition Phospholipids Glycolipids and Cholesterol Asymmetric Organization of Lipids in the Bilayer Bilayer Couple Effect Membrane Phosphoinositides Lipid Mobility Lateral Diffusion Lipid Renewal Pathways MEMBRANE…
Chapter Outline PLATELET MORPHOLOGY AND SUBCELLULAR ORGANIZATION PLATELET GENOMICS AND PROTEOMICS ANTITHROMBOTIC COMPONENTS OF THE VESSEL WALL REACTING TO THE BREACH: CELL SURFACE RECEPTORS THAT MEDIATE TETHERING AND ADHESION AND…
