Summary of Key Points • 18 F-2-deoxy- d -glucose (FDG)-positron emission tomography–computed tomography (PET–CT) is routinely used clinically for diagnosis, staging, and radiation treatment planning and may have a role…
Summary of Key Points • In the context of disease confined to the chest, mediastinal staging is crucial for determining the best curative treatment strategy, especially for nonsmall cell lung…
Summary of Key Points • Low-dose multidetector computed tomography (CT) screening of active and former heavy smokers has been shown to decrease lung cancer mortality. • The malignant potential of…
Key wordsAnatomic pathology, Cytology sample, Lung cancer classification, Pathologic classification of lung cancer, Pathologic diagnosis, Resected tumor, Small biopsy specimen, Tissue management Summary of Key Points • A clinically…
Summary of Key Points • Techniques for the optimal triage and preparation of small specimens for diagnosis and ancillary studies are provided. • For optimal results, a standardized protocol and…
Summary of Key Points • Of key importance is whether a prognostic marker is also a predictive marker for therapeutic benefit. • As predictive biomarkers become integral in the use…
Summary of Key Points • Most people with lung cancer are symptomatic at the time of initial presentation; however, between 5% and 15% of people may be asymptomatic. • Alarming…
Summary of Key Points • Humoral and cellular immune dysregulation in the tumor microenvironment contributes to immune evasion, a key hallmark of lung cancer. • Immunosuppressive mechanisms observed in lung…
Summary of Key Points • The biologic roles of microRNAs (miRNAs) in lung cancer indicate their correlation with disease status, prognosis, and therapeutic outcome. The discovery of miRNAs has opened…
Summary of Key Points • There is untapped potential for targeted lung cancer prevention and therapy that requires, as a first step, a more clear delineation of the biology underlying…
