Animal Models of Human Granulocyte Diseases

Sep 16, 2017 by in HEMATOLOGY Comments Off on Animal Models of Human Granulocyte Diseases

In vivo animal models have proven very useful to the understanding of basic biologic pathways of the immune system, a prerequisite for the development of innovate therapies. This article addresses…

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Leukocyte Adhesion Deficiencies

Sep 16, 2017 by in HEMATOLOGY Comments Off on Leukocyte Adhesion Deficiencies

During inflammation, leukocytes play a key role in maintaining tissue homeostasis through elimination of pathogens and removal of damaged tissue. Leukocytes migrate to the site of inflammation by crawling over…

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Defective G-CSFR Signaling Pathways in Congenital Neutropenia

Sep 16, 2017 by in HEMATOLOGY Comments Off on Defective G-CSFR Signaling Pathways in Congenital Neutropenia

Several signaling systems downstream of G-CSFR have been identified that are defective or hyperactivated in myeloid cells of patients with congenital neutropenia: severely reduced expression of myeloid-specific transcription factors LEF-1…

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Genetics and Pathophysiology of Severe Congenital Neutropenia Syndromes Unrelated to Neutrophil Elastase

Sep 16, 2017 by in HEMATOLOGY Comments Off on Genetics and Pathophysiology of Severe Congenital Neutropenia Syndromes Unrelated to Neutrophil Elastase

Considerable progress has been made in recent years in understanding of the genetic basis for congenital neutropenia syndromes. With the advent of high-throughput genomic analyzing technologies, the underlying genetic causes…

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Epidemiology of Congenital Neutropenia

Sep 16, 2017 by in HEMATOLOGY Comments Off on Epidemiology of Congenital Neutropenia

Epidemiologic investigations of congenital neutropenia aim to determine several important indicators related to the disease, such as incidence at birth, prevalence, and outcome in the population, including the rate of…

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Animal Models of Human Granulocyte Diseases

Mar 1, 2017 by in HEMATOLOGY Comments Off on Animal Models of Human Granulocyte Diseases

In vivo animal models have proven very useful to the understanding of basic biologic pathways of the immune system, a prerequisite for the development of innovate therapies. This article addresses…

read more
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