SPECT/CT, PET/CT and PET/MR Principles
. In tomography, the voxel value in a transverse slice is reconstructed from different LORs passing through all the voxels of this slice. As a result, the noise in a…
Internal Dosimetry: Principles and Applications to NET
The SI unit for absorbed dose is joule per kilogram (J kg−1) and its special name is gray (Gy) [11]. In nuclear medicine represents the number of radionuclide disintegrations in…
Radionuclide Imaging of Gastrointestinal Neuroendocrine Tumors
Frequent clinical features Secretion Management (first line) Stomach Mainly endoscopic discoverya Rare Depends on type (see text) Small intestine Often discovered on complication (obstruction, perforation, bleeding) Liver metastasis Carcinoid…
Radionuclide Imaging of Head and Neck Paragangliomas
Fig. 13.1 Jugular PGL. Co-registered axial planes in MR TOF (time of flight) without gadolinium, CT (bone kernel), and MR TOF—CT rigid fusion with PGLs drawn in orange. 1 Jugular…
Principles and Application of Molecular Imaging for Personalized Medicine and Guiding Interventions in Neuroendocrine Tumors
Fig. 10.1 Contrasting strengths and weaknesses of both anatomic and molecular imaging. The fusion of both modalities with hybrid PET/CT or PET/MRI enables the evaluation of function and anatomy contemporaneously…
Radionuclide Imaging of Chromaffin Cell Tumors
First syndromic manifestation Context at PPGL presentation (in index cases) PHEO at presentation Additional extra-adrenal PGL Predominant secretion PPGL-associated malignancy risk MEN2 MTC Adult Possible phenotypic features of MEN2…
Radionuclide Imaging of Pheochromocytoma and Paraganglioma in the Era of Multi-omics
Fig. 12.1 1H-NMR spectra of PPGLs. One-dimensional 500 MHz 1H-NMR spectra of PPGL tumor tissues at pH 2.50. Upper panel, sporadic tumor showing normal tumor metabolites like lactic acid, acetic…
Radionuclide Imaging of Medullary Thyroid Carcinoma
PET tracer Pooled detection rate for PET/CT Correlation between detection rate and serum calcitonin values Prognostic value Tolerance Radiation dose Radionuclide production Comparative costs Comparative availability Theranostic value FDG 59…
Nanoparticles for Radionuclide Imaging and Therapy: Principles
and Philippe Barthélémy1, 3 (1) Université de Bordeaux, Bordeaux, F-33076, France (2) CNRS, INCIA, UMR 5287, F-33400 Talence, France (3) INSERM U1212, UMR CNRS 5320, Bordeaux, F-33076, France Philippe Barthélémy Email:…
Radionuclide Imaging of Pulmonary and Thymic Neuroendocrine Tumors
Variable Typical carcinoid Atypical carcinoid Large cell NEC Small cell NEC Mitoses per 2 mm2 (10HPF) <2 2–10 ≥10 ≥10 Necrosis Absent Often punctate Often, large zones Frequent, large zones…
