Preclinical Approaches to the Protection of Ovarian Function

Jul 13, 2019 by in ONCOLOGY Comments Off on Preclinical Approaches to the Protection of Ovarian Function

Keywords apoptosis, chemotherapy, fertility, ovary, preservation, primordial follicles   9.1 Introduction Recent advances in our understanding of the mechanisms underlying the impact of cytotoxic drugs on the ovary have opened…

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Ovarian Tissue Cryopreservation for Fertility Preservation

Jul 13, 2019 by in ONCOLOGY Comments Off on Ovarian Tissue Cryopreservation for Fertility Preservation

Keywords autotransplantation, fertility preservation, malignant cell contamination, outcome, ovarian tissue cryopreservation   7.1 Overview The survival rate among the ~2% of women of reproductive age who have suffered from invasive…

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In Vitro Models of Ovarian Toxicity

Jul 13, 2019 by in ONCOLOGY Comments Off on In Vitro Models of Ovarian Toxicity

Keywords animal models, apoptosis, chemotherapy, culture, follicle, in vitro , ovary, primary effects   6.1 Introduction Investigating the precise effect of chemotherapy on female fertility is a key research aspect…

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Current Clinical Approaches to Protecting the Ovary: GnRH Analogues

Jul 13, 2019 by in ONCOLOGY Comments Off on Current Clinical Approaches to Protecting the Ovary: GnRH Analogues

Keywords chemotherapy, fertility preservation, gonadotoxicity, gonadotropin-releasing hormone (GnRH) agonist, ovarian protection   8.1 Introduction Cancer is not uncommon and no longer considered as an incurable disease among reproductive-age women. Indeed,…

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In Vivo Models of Ovarian Toxicity

Jul 13, 2019 by in ONCOLOGY Comments Off on In Vivo Models of Ovarian Toxicity

Keywords bortezomib, chemotherapy, dexrazoxane, fertility preservation, in vivo animal models, mice, non-human primates, ovary, ovarian toxicity, ovoprotectant   5.1 Introduction The success of cancer treatment creates a growing population of…

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Clinical Assessment of Ovarian Toxicity

Jul 13, 2019 by in ONCOLOGY Comments Off on Clinical Assessment of Ovarian Toxicity

Keywords anti-Müllerian hormone, antral follicle count, chemotherapy, infertility, ovarian reserve, premature ovarian insufficiency   3.1 Introduction Assessment of ovarian toxicity in the clinical setting is important in determining the effects…

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Ovarian Follicle Biology and the Basis for Gonadotoxicity

Jul 13, 2019 by in ONCOLOGY Comments Off on Ovarian Follicle Biology and the Basis for Gonadotoxicity

Keywords endocrine system, follicle, follicle activation, follicle death, folliculogenesis, ovarian hormones, ovarian reserve, ovary   1.1 Overview of Ovarian Function The ovary serves two roles – the production of hormones…

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