Oncohema Key

Keywords apoptosis, chemotherapy, fertility, ovary, preservation, primordial follicles   9.1 Introduction Recent advances in our understanding of the mechanisms underlying the impact of cytotoxic drugs on the ovary have opened…

Keywords autotransplantation, fertility preservation, malignant cell contamination, outcome, ovarian tissue cryopreservation   7.1 Overview The survival rate among the ~2% of women of reproductive age who have suffered from invasive…

Keywords animal models, apoptosis, chemotherapy, culture, follicle, in vitro , ovary, primary effects   6.1 Introduction Investigating the precise effect of chemotherapy on female fertility is a key research aspect…

Keywords bortezomib, chemotherapy, dexrazoxane, fertility preservation, in vivo animal models, mice, non-human primates, ovary, ovarian toxicity, ovoprotectant   5.1 Introduction The success of cancer treatment creates a growing population of…

Keywords anti-Müllerian hormone, antral follicle count, chemotherapy, infertility, ovarian reserve, premature ovarian insufficiency   3.1 Introduction Assessment of ovarian toxicity in the clinical setting is important in determining the effects…

Keywords amenorrhoea, BRCA genes, chemotherapy, DNA double-strand breaks, ovarian damage   4.1 Introduction Chemotherapy has considerably improved survival of many cancer types; however, a patient’s quality of life is influenced…

Keywords chemotherapy, granulosa cells, oocytes, primary ovarian insufficiency, radiotherapy   2.1 Introduction More than 75% of children treated for malignant disease will be alive 10 years following initial diagnosis in…

Keywords endocrine system, follicle, follicle activation, follicle death, folliculogenesis, ovarian hormones, ovarian reserve, ovary   1.1 Overview of Ovarian Function The ovary serves two roles – the production of hormones…