and Treatment of Primary Immune Thrombocytopenia in Children
Study No. of patients Age at ITP diagnosis (year) Duration before rituximab (month) Age at rituximab treatment (year) Times of injection Duration of observation (month) Rate of initial response (CR…
Membrane Glycoproteins
Ligand Functions Copies/platelet Integrins αIIbβ3 (GPIIb-IIIa) Fibrinogen Aggregation, adhesion ~80,000 α2β1 (GPIa-IIa) Collagen Adhesion 3000–5000 α5β1 (VLA-5) Fibronectin Adhesion 1000 α6β1 (VLA-6) Laminin Adhesion 1000 αvβ3 Vitronectin Adhesion 100…
Diagnosis: Hypoplastic Thrombocytopenia
Decreased platelet production (hypoplastic thrombocytopenia) Aplastic anemia (AA) Amegakaryocytic thrombocytopenia Acute leukemia Chemotherapy-induced thrombocytopenia (CIT) Myelodysplastic syndrome (MDS) Malignancy with bone marrow infiltration or suppression (e.g., lymphoma, leukemia, solid tumors) Increased…
and Thrombopoiesis
Fig. 1 Megakaryopoiesis and thrombopoiesis. Differentiation from hematopoietic stem cells (HSCs) to platelets proceeds by a number of intermediate stages. Megakaryopoiesis contains stages from HSC to mature MKs in the…
Diagnosis: Congenital Macrothrombocytopenia
Platelet size Disease OMIM Inheritance Gene Features Small Wiskott-Aldrich syndrome 301000 X WAS Immunodeficiency X-linked thrombocytopenia 313900 X WAS No immunodeficiency FYB thrombocytopenia na AR FYB Activated platelets Normal ANKRD26…
in General
Artificial thrombocytopenia Platelet aggregation caused by insufficient anticoagulation Platelet aggregation caused by EDTA-dependent immunoglobulin (pseudothrombocytopenia) Giant platelets Decreased platelet production Congenital thrombocytopenia MYH9-related macrothrombocytopenia Wiskott-Aldrich syndrome Congenital amegakaryocytic thrombocytopenia (CAMT),…
Manifestations of ITP in Children
Newly diagnosed ITP Resolution within 3 months of diagnosis Persistent ITP Resolution 3–12 months from diagnosis; includes patients not reaching spontaneous remission or not maintaining complete response off therapy Chronic…
in Pregnancy
International consensus report ASH BSCH Japan First-line Prednisone/prednisolone (10–20 mg/day) IVIG (dose not specified) IV anti-D Prednisone/prednisolone (1 mg/kg/day) IVIG (1 g/kg for 2 days) Prednisone/prednisolone (1 mg/kg/day) IVIG…
Transfusion
Bleeding risk Reference Fever (38.5 °C<) [13] Infection [13] Anticoagulant drugs [14] Amphotericin use [10, 15] Hypoalbuminemia [16] Uremia [16] Recent bleeding episodes [16] Recent bone marrow transplantation [16] Acute…
