Primary Prevention of Breast Cancer
Abstract This chapter reviews 20 years of randomized, prospective clinical research on the use of selective hormone receptor modulators and aromatase inhibitors for the reduction of breast cancer risk in…
ONCOLOGY
Molecular Prognostic Factors for Breast Carcinoma
Abstract Molecular genomic testing provides clinicians with prognostic and predictive information that can help individualize treatment, decrease the risk of over- or under-treatment, and, accordingly, improve outcomes. In this chapter,…
Paget Disease of the Breast
Abstract Paget disease (PD) is defined as the presence of neoplastic cells of glandular differentiation, interspersed between keratinocytes of nipple epidermis, and constitutes approximately 1% of breast cancer cases. More…
Clinically Established Prognostic Factors in Breast Cancer
Abstract Prognostic factors are quantifiable data that provide information regarding the expected outcome for patients with a particular disease prior to therapy. Importantly, though, these prognostic values provide information on…
Epidemiology of Breast Cancer
Abstract Multiple studies provide estimates of the risk of breast cancer for women. Dense breasts on mammography or having first-degree relatives with breast cancer are associated with at least a…
History of the Therapy of Breast Cancer
Abstract This chapter provides the reader with an overview of the key milestones in the development of the current understanding and management of breast cancer. Although the milestones listed here…
Benign, High-Risk, and Premalignant Lesions of the Breast
Abstract This chapter presents a histopathologic classification of the wide variety of noncancerous lesions identified in the human female breast, stratified into categories that predict breast cancer risk in broad…
Breast Physiology: Normal and Abnormal Development and Function
Abstract The mammary gland is composed of an epithelial system of ducts and lobuloalveolar secretory units embedded in a mesenchymally derived fat pad. The growth and morphogenesis of the epithelial…
Mastitis and Breast Abscess
Abstract Breast abscess is a common clinical problem. Management of these patients can be challenging and requires an understanding of pathophysiology and microbiology to achieve optimal outcomes. This chapter also…
Gynecomastia
Abstract Gynecomastia is benign enlargement of the male breast due to proliferation of the glandular component. This common clinical condition, which may be unilateral or bilateral, presents as an incidental…
