Radiographic Evaluation of Cancer
Imaging Goals Goals of radiographic imaging vary in patients with malignancies depending upon whether the specific malignant diagnosis is already known and whether the imaging is performed to stage disease…
ONCOLOGY
The Role of Molecular Probes and Other Markers in the Diagnosis of Malignancy
Tad Wieczorek Janina A. Longtine Histopathologic assessment is still the cornerstone in the diagnosis, classification, and grading of malignancies. Light microscopic evaluation augmented by histochemical stains is sufficient in the majority of…
Preclinical Approaches to the Protection of Ovarian Function
Keywords apoptosis, chemotherapy, fertility, ovary, preservation, primordial follicles 9.1 Introduction Recent advances in our understanding of the mechanisms underlying the impact of cytotoxic drugs on the ovary have opened…
Ovarian Tissue Cryopreservation for Fertility Preservation
Keywords autotransplantation, fertility preservation, malignant cell contamination, outcome, ovarian tissue cryopreservation 7.1 Overview The survival rate among the ~2% of women of reproductive age who have suffered from invasive…
In Vitro Models of Ovarian Toxicity
Keywords animal models, apoptosis, chemotherapy, culture, follicle, in vitro , ovary, primary effects 6.1 Introduction Investigating the precise effect of chemotherapy on female fertility is a key research aspect…
Current Clinical Approaches to Protecting the Ovary: GnRH Analogues
Keywords chemotherapy, fertility preservation, gonadotoxicity, gonadotropin-releasing hormone (GnRH) agonist, ovarian protection 8.1 Introduction Cancer is not uncommon and no longer considered as an incurable disease among reproductive-age women. Indeed,…
In Vivo Models of Ovarian Toxicity
Keywords bortezomib, chemotherapy, dexrazoxane, fertility preservation, in vivo animal models, mice, non-human primates, ovary, ovarian toxicity, ovoprotectant 5.1 Introduction The success of cancer treatment creates a growing population of…
Clinical Assessment of Ovarian Toxicity
Keywords anti-Müllerian hormone, antral follicle count, chemotherapy, infertility, ovarian reserve, premature ovarian insufficiency 3.1 Introduction Assessment of ovarian toxicity in the clinical setting is important in determining the effects…
The Current Understanding of Clinical Data on Ovarian Toxicity from Cancer Treatment
Keywords amenorrhoea, BRCA genes, chemotherapy, DNA double-strand breaks, ovarian damage 4.1 Introduction Chemotherapy has considerably improved survival of many cancer types; however, a patient’s quality of life is influenced…
Relevant Cancer Diagnoses, Commonly Used Chemotherapy Agents and Their Biochemical Mechanisms of Action
Keywords chemotherapy, granulosa cells, oocytes, primary ovarian insufficiency, radiotherapy 2.1 Introduction More than 75% of children treated for malignant disease will be alive 10 years following initial diagnosis in…
