Keywords Cancer, vaccines, poxviruses, TRICOM, immunotherapy, intratumoral vaccination, immunostimulatory molecules, costimulatory molecules   In this chapter, we review the use of recombinant poxviral vectors containing transgenes for costimulatory molecules and…

Keywords FDA, CBER, cancer gene therapy, regulatory review, CMC, pharmacology/toxicology, clinical, drug development   Introduction FDA’s Regulatory Responsibility and Gene Therapy Submissions In the United States, the U.S. Food and…

Keywords MGMT, P140K, chemoprotection, drug-resistance gene therapy, hematopoietic stem cell gene therapy, glioblastoma   Introduction to MGMT Gene Transfer in Cancer Therapeutics The O 6 -methylguanine methyltransferase (MGMT) catalytic protein…

Keywords Sodium iodide symporter (NIS), viral vector, lentivirus, radioiodide, tumor-specific targeting promoter   Sodium Iodide Symporter Thyroid hormone synthesis requires a variety of molecules in thyroid follicular cells, including sodium…

Keywords Gene therapy, hematopoiesis, cytidine deaminase, doxycycline, miRNA, Ara-C   Background Transfer of Drug-Resistance Genes into Hematopoietic Stem Cells Given their ability to self-renewal, proliferate extensively, and differentiate into all…

Keywords Salmonella , genetic engineering, gene delivery, gene therapy, attenuation, toxicity, imaging   Introduction Gene therapy is considered to be one of the most promising therapeutic approaches for treating cancer,…

Keywords IL-12, adenovirus, RheoSwitch®, activator ligand, dendritic cells, controlled expression, intratumoral, immunotherapy   Introduction Tumors grow aggressively, are invasive, and may spread to distant metastatic sites, not only because of…

Keywords Gene therapy, drug resistance, glioblastoma, chemoprotection, in vivo selection, MGMT, hematopoietic stem cell, temozolomide   Introduction Gene therapy was initially developed as an ideal treatment for defective single-gene diseases…