Drug name Generic name Target Status Reversible ZD1839 Gefitinib EGFR Approved OSI776 Erlotinib EGFR Approved BPI-2009H Icotinib EGFR Approved TAK-165 Mubritinib EGFR/ERBB2 Phase I XL647 NA EGFR/ERBB2/FLT-4 Phase II…
Risk factor Risk ratio Comments References Second hand smoke 1.34 Prospective nested case control in Europe [27] 1.23 (spouse) 1.27 (workplace) Pooled analysis from two case controls US & Europe…
Fig. 1 A simplified overview of platinum resistance in lung cancer. Pt platinum, CTR1 copper transporter 1, GSH glutathione, BCRP breast cancer resistance protein Table 1 Tumor factors contributing to…
Fig. 1 Prevalence of current cigarette smoking, by race/ethnicity and sex, 2010, National Health Interview Survey, United States [2] While personal cigarette smoking has been causally linked with lung cancer,…
Fig. 1 Vascular endothelial growth factor receptor signal transduction (Reprinted with permission from Roskoski. CROH 2007 62(3):179–213) The role of serum VEGF (VEGF-A) in tumor growth and development has been…
© Springer International Publishing Switzerland 2016Aamir Ahmad and Shirish Gadgeel (eds.)Lung Cancer and Personalized MedicineAdvances in Experimental Medicine and Biology89310.1007/978-3-319-24223-1_9 Anaplastic Lymphoma Kinase (ALK) Signaling in Lung Cancer Sai-Hong Ignatius Ou1 and Keisuke Shirai2 (1) Chao Family…
Fig. 1 Ways to leave your EGFR inhibitor: biochemical pathways leading to resistance to small molecule EGFR drugs such as gefitinib and erlotinib. (a) Structures of two approved EGFR TKIs,…
Parameter Group EO EC BF R (mm) Controls 2.0 1.9 2.3 #,$ (1.7–2.6) (1.6–2.6) (1.8–2.8) OA 2.7** 2.8*** 3.2***,## (2.4–3.4) (2.2–3.8) (2.5–4.1) RA 2.6** 2.8** 3.3***,###,$$ (2.1–3.4) (2.1–3.4) (2.7–4.1) A…
Fig. 1 Decreased Cath V (a), increased endostatin (b) and IL-18 (c) in BALF of Besnier-Boeck-Schaumann disease (BBS) patients as compared with healthy volunteers ROC curves for Cath V, endostatin,…
