The disciplines of epidemiology and biostatistics apply to gynecologic oncology in defining cancer occurrence and survival, identifying risk factors, and implementing strategies for treatment or prevention, including the proper design…
Worldwide, 6,044,000 women are diagnosed with cancer and 3,345,000 die from the disease each year (1). From 1975–2010, the age-standardized incidence rates for cancers in women have increased by 42%…
For most women, a diagnosis of gynecologic cancer is a crisis, and it is essential to consider a patient’s psychological and behavioral responses when managing her disease. While most patients…
Cancer is diagnosed in 1 per 1,000 to 2,000 pregnancies, and is likely to increase with childbearing being delayed until higher maternal age in developed countries (1,2). Pregnancy does not…
Cancer is caused by a series of events that include the accumulation of successive molecular lesions and alterations in the tumor microenvironment (1). Molecular lesions include overexpression, amplification, or mutations…
Tumor and Normal Tissue Response to Radiotherapy Richard P. Hill and Robert G. Bristow 16.1 Introduction 16.2 Principles of Clinical Radiotherapy 16.2.1 Radiotherapy Dose 16.2.2 Radiotherapy Planning and Dose Delivery…
Methods of Molecular Analysis Anthony M. Joshua, Paul C. Boutros, and Thomas Kislinger 2.1 Introduction 2.2 Principal Techniques for Nucleic Acid Analysis 2.2.1 Cytogenetics and Karyotyping 2.2.2 Hybridization and Nucleic…
Cancer Epidemiology Gord Fehringer, Rayjean J. Hung, and Geoffrey Liu 3.1 Introduction and Terminology 3.1.1 Epidemiology: Definition and Scope 3.1.2 General Approach 3.1.3 Role of Epidemiology in Translational Medicine 3.2…
Pharmacology of Anticancer Drugs Eric X. Chen 18.1 General Principles of Pharmacology 18.1.1 Pharmacokinetics and Pharmacodynamics 18.1.2 Dosing of Chemotherapy in Individual Patients 18.1.3 Pharmacogenetics 18.2 Alkylating Agents 18.2.1 Nitrogen…
Molecular and Cellular Basis of Radiotherapy Shane M. Harding, Richard P. Hill, and Robert G. Bristow 15.1 Introduction 15.2 Interaction of Radiation with Matter 15.2.1 Types of Radiation, Energy Deposition,…
