Genetic Profiling in Colorectal Cancer
20 Genetic Profiling in Colorectal Cancer Debashish Bose, Nita Ahuja KEY POINTS • Genetic profiling is the attempt to classify disease states by the molecular characteristics of tumor tissue or…
ONCOLOGY
Systemic Therapy for Colon Cancer
15 Systemic Therapy for Colon Cancer Khaled El-Shami, Sujatha Nallapareddy, Wells Messersmith KEY POINTS • Systemic therapy for colorectal cancer is rapidly changing, with six new drugs introduced during the…
Vaccines and Immunotherapy
19 Vaccines and Immunotherapy Ajay Jain, Richard Schulick KEY POINTS • Immunotherapy is a therapeutic strategy in which a patient’s immune responses are modulated to eradicate malignant cancer cells. •…
Chemoprevention of Colorectal Cancer
6 Chemoprevention of Colorectal Cancer Melissa A. Munsell, Francis M. Giardiello KEY POINTS • The chemopreventive effect of nonsteroidal anti-inflammatory drugs (NSAIDs) is supported by in vitro experiments, animal models,…
Limited Resection: Indications, Techniques, and Outcomes of Transanal Excision and Transanal Endoscopic Microsurgery
12 Limited Resection: Indications, Techniques, and Outcomes of Transanal Excision and Transanal Endoscopic Microsurgery Elizabeth C. Wick KEY POINTS • Local excision is applicable in a select subset with early…
Endoscopic Techniques in Colorectal Neoplasia
13 Endoscopic Techniques in Colorectal Neoplasia Eun Ji Shin, Samuel A. Giday KEY POINTS • Endoscopic techniques that are discussed include endoscopic resection and colonic stenting. • Endoscopic resections are…
Stool and Blood Sampling for Early Detection of Colorectal Cancer
9 Stool and Blood Sampling for Early Detection of Colorectal Cancer Jason K. Sicklick, Nita Ahuja KEY POINTS • Screening methods have been applied for the detection of premalignant colonic…
Radiation Therapy for Colorectal Adenocarcinoma: External Beam and Intraoperative Radiation Therapy
16 Radiation Therapy for Colorectal Adenocarcinoma: External Beam and Intraoperative Radiation Therapy Joseph M. Herman, Timothy M. Pawlik KEY POINTS • Despite aggressive surgical management, up to 40% of patients…
Presentation and Initial Evaluation of Colorectal Cancer
2 Presentation and Initial Evaluation of Colorectal Cancer Susan Tsai, Susan L. Gearhart KEY POINTS • In the United States, nearly 85% of patients with colorectal cancer (CRC) are symptomatic…
Colonoscopy and Flexible Sigmoidoscopy in Colorectal Cancer Screening and Surveillance
8 Colonoscopy and Flexible Sigmoidoscopy in Colorectal Cancer Screening and Surveillance Michelle N. Zikusoka, John H. Kwon KEY POINTS • Persons with average risk for colorectal cancer should undergo flexible…
