Tumor antigenicity and cancer as non-self
Summary of key facts • Professor Paul Ehrlich is credited with introducing the concept of cancers as non-self and proposing the concept of tumor immune surveillance in 1909. • Evidence…
Summary of key facts • Professor Paul Ehrlich is credited with introducing the concept of cancers as non-self and proposing the concept of tumor immune surveillance in 1909. • Evidence…
Summary of key facts • The innate immune system is the host’s first line of immune defense against challenges of the environment. • The innate immune system response is a…
Summary of key facts • The complement system is a key component of the innate immune system, responsible for facilitating immune defense mechanisms, regulating inflammation, and maintaining tissue homeostasis. •…
Summary of key facts • Immunoglobulins (Igs) are the soluble mediators of antigen recognition. An Ig that is capable of specifically binding an antigen is termed an antibody . •…
Summary of key facts • The lymphatic system is a complex, blind-ended vascular tree distinct and separate from the blood circulatory system. • Lymphatics facilitate tissue fluid homeostasis, nutrient uptake,…
PHARYNX (ICD‐O C01, C05.1, 2, C09, C10.0, 2, 3, C11–13) Rules for Classification The classification applies only to carcinomas. There should be histological confirmation of the disease. Anatomical Sites and…
BREAST TUMOURS (ICD‐O‐3 C50) Rules for Classification The classification applies only to carcinomas and concerns the male as well as the female breast. There should be histological confirmation of the…
LUNG (ICD‐O C34) Rules for Classification The classification applies to carcinomas of the lung, including non‐small cell carcinomas, small cell carcinomas and bronchopulmonary carcinoid tumours. It does not apply to…
MALIGNANT MELANOMA OF SKIN (ICD‐O‐3 C44, C51.0, C60.9, C63.2) Rules for Classification There should be histological confirmation of the disease. Regional Lymph Nodes The regional lymph nodes are those appropriate…
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