Gompertzian growth kinetics Fig. 8.1 Fig. 8.2 Norton-Simon hypothesis: progressive improvements in drug response do not change actual cancer survival 8.2 Intraperitoneal Chemotherapy: Physical and Biological Principles The pharmacological rationale…
• T stage of primary (T4) • Lymph-node status (N1-2) • Mucinous/signet-ring-cell histology • Right-sided tumors • Positive peritoneal cytology • Emergency/nonradical surgery • Perforated/ruptured primary • Ovarian metastases •…
Types Subtypes Percentage Malignant Epithelial 75 Tubulopapillary nonglandular (solid) 13 Sarcomatous 6 Biphasic (mixed) 6 Undifferentiated Very rare Desmoplastic Very rare Lymphohistiocytic Very rare Small cell Very rare Deciduoid Very…
Fig. 13.1 Peritoneal carcinomatosis from ovarian cancer: involvement of lesser omentum and hepatoduodenal ligament Fig. 13.2 Lesser omentectomy and stripping of the omental bursa floor Another challenging problem, especially in…
Patient Age Sex Primary HIPEC PCI CC FU Surv 1 72 M Sarcoma Oxal 20 1 DOD 12 2 77 F Sarcoma Oxal 16 0 AWD 11 3 61 M…
, Francesca Guerini, Andrea Zanoni and Giovanni de Manzoni (1) Department of Surgery, Upper G.I. Surgery Unit, Borgo Trento Hospital, Verona, Italy 5.1 Introduction An accurate staging system for cancer diseases aims at…
Study [Reference] Year Patients Drug Temperature (°C) Duration Mortality Morbility Survival Yan et al. [22] 2007 34 CDDP 120 mg + MMC 30 mg 42.5–43.5 60–90 – 14.7% 3 yrs…
Fig. 10.1 Hyperthermic intraperitoneal chemotherapy (HIPEC): peritoneal cavity expander. (Courtesy of Prof. Angelo Di Giorgio) A roller pump forces chemotherapy perfusion into the abdomen through the Tenckhoff catheter and extracts…
Fig. 16.1 Perforated appendiceal tumor [low-grade appendiceal mucinous neoplasms (LAMN II)] 16.3 Clinical Features PMP usually manifests with the characteristic jelly belly (Fig. 16.2) appearance, represented by the advanced stage…
Fig. 21.1 Proposed models for the development of types 1 and 2 tumors of the ovary. SCOUT, secretory cell outgrowths; P53, tumor protein 53; STIC, serous tubal intraepithelial carcinoma; PPSPC,…
