NEUROBORRELIOSIS: NERVOUS SYSTEM INVOLVEMENT WITH BORRELIA SPECIES JOHN J. HALPERIN, SVEN BERGSTRÖM, AND GARY P. WORMSER Relapsing fever and Lyme disease, infections most commonly acquired through bites of hematophagous arthropods,…
HUMAN PRION DISEASES SERGGIO C. LANATA, SVEN FORNER, AND MICHAEL D. GESCHWIND The transmissible spongiform encephalopathies (TSEs) are a group of closely related fatal neurodegenerative diseases that affect humans and…
ENCEPHALITIS CAROL GLASER AND ARUN VENKATESAN Encephalitis is one of the most challenging syndromes for clinicians to manage. Patients are often critically ill, and there are many potential etiologies. Despite…
FREE-LIVING AND PARASITIC AMEBIC INFECTIONS SHANNON MOONAH AND WILLIAM A. PETRI, JR. Central nervous system (CNS) infection with free-living and parasitic amebae is rare but life threatening. Three separate clinical…
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INFECTIONS DUE TO NONTUBERCULOUS MYCOBACTERIA JEANA L. BENWILL AND RICHARD J. WALLACE, JR. Mycobacteria other than Mycobacterium tuberculosis have established themselves as human pathogens. By 1960, most of the common…
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WHIPPLE’S DISEASE MATTHIAS MAIWALD AND DAVID A. RELMAN In a seminal autopsy report in 1907, George H. Whipple provided a thorough and articulate description of the disease that now bears…
VACCINES AGAINST BACTERIAL MENINGITIS AMANDA C. COHN AND NANCY E. MESSONNIER Three major pathogens—Haemophilus influenzae type b (HIB), Neisseria meningitidis (meningococcus), and Strep tococcus pneumoniae (pneumococcus)—cause the majority of bacterial…
