Chapter Outline CHEMOTHERAPEUTIC AGENTS CLINICAL APPLICATION OF CHEMOTHERAPY CHEMOTHERAPY IN CHILDREN PHARMACOKINETIC CHANGES DURING CHILDHOOD Absorption Volume of Distribution Hepatic Metabolism Renal and Hepatic Excretion Influence of Underlying Disease on…
Chapter Outline CLASSIFICATION Morphologic and Cytochemical Classification Immunophenotype MOLECULAR PATHOGENESIS Transcriptional Regulators Growth Factor Signaling Molecular Pathogenesis of Select High-Risk Subtypes CLINICAL MANIFESTATIONS Peripheral Blood Bone Marrow Extramedullary Leukemia DIFFERENTIAL…
Chapter Outline DNA-BASED METHODS Comparative Genomic Hybridization Genotyping Capillary (Sanger) Sequencing Pyrosequencing DNA Microarrays Single Nucleotide Polymorphism Arrays Chromatin Immunoprecipitation, ChIP-Chip, ChIP-Seq Genome-Wide Association Studies Exome Sequencing/Targeted Sequencing Whole Genome…
Chapter Outline LYMPHADENOPATHY Approach to the Patient EMERGENCIES IN PATIENTS WITH NEWLY DIAGNOSED LYMPHOMA HODGKIN LYMPHOMA Classic Hodgkin Lymphoma Nodular Lymphocyte-Predominant Hodgkin Lymphoma Treatment of Relapsed Hodgkin Lymphoma Late Effects…
Chapter Outline LYMPHOCYTE DEVELOPMENT LYMPHOCYTE SPECIFICITY B-CELL ONTOGENY Immunoglobulin Structure Immunoglobulin Rearrangement and B-Cell Maturation in Bone Marrow Peripheral B-Cell Maturation and Differentiation T-CELL ONTOGENY T-Cell Receptor Subtypes and Specificity…
Chapter Outline TRADITIONAL CHEMOTHERAPY Conventional Chemotherapeutic Approaches: Not Entirely Nonspecific Lessons Learned from Cytotoxic Chemotherapy Shortcomings of Cytotoxic Chemotherapy INTRODUCTION TO TARGETED THERAPY What is Targeted Therapy? Advantages of Targeted…
Chapter Outline PEDIATRIC VERSUS ADULT CANCERS CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA AS A MODEL OF CLONAL EVOLUTION EVOLUTIONARY PENETRANCE OF DISEASE EVOLUTIONARY DYNAMICS AND CLINICAL OUTCOME “Nothing in biology makes sense…
Chapter Outline HEREDITARY SPHEROCYTOSIS History Prevalence and Genetics Clinical Presentation Etiology: Membrane Protein Defects Pathophysiology Laboratory Characteristics Differential Diagnosis Conditions That Camouflage Hereditary Spherocytosis Complications Splenectomy Other Therapies Animal and…
Chapter Outline PREVALENCE AND MULTIPLE CAUSES OF ANEMIA IN THE THIRD WORLD HEMATOLOGIC CHANGES ASSOCIATED WITH SPECIFIC INFECTIONS IN THE TROPICS Malaria Visceral Leishmaniasis (Kala-azar) Schistosomiasis Trypanosomiasis Hookworm Bartonellosis Complex…
Chapter Outline HUMAN HEMOGLOBINS: COMPOSITION AND GENETICS Globin Gene Structure Regulation of Globin Gene Expression CLASSIFICATION OF THE THALASSEMIAS Origin of Thalassemia Mutations: The Influence of Malaria Classes of Mutations…
