6.1 Developmental origin of osteoblasts 6.1.1 Control of osteoblast function 6.1.1.1 Signaling pathways that control bone formation Osteoblasts originate from mesenchymal stromal cells (MSCs) that represent the primary cells that…
4.1 Introduction The lineage relationships and kinetics of the cellular components of bone are the focus of this chapter. Tissues in mammals are generally maintained by one of two schemas,…
3.1 Overview The skeletal system consists of 206 bones of strikingly varying shapes, sizes, and functions. More than with any other organ, the specific shapes and sizes of these bones…
1.1 Defining osteoporosis This chapter introduces the topic of osteoporosis from the perspective of the bone. Its purpose is to consider the definition of osteoporosis and to discuss the nature…
3Short Stature Introduction Definitions of short stature, failure to thrive, and growth failure Physiology of growth Endocrine control of growth Clinical assessment of growth Clinical assessment of short stature Investigation…
1Diabetes Mellitus Definition Incidence Biochemistry Clinical presentation Investigations Initial management of newly diagnosed type 1 diabetes Insulin therapy in type 1 diabetes Dietary management Management of the child presenting with…
10Calcium and Bone Physiology Hypocalcaemia Treatment Rickets Osteoporosis Hypercalcaemia When to involve a specialist centre Transition Future developments Controversial points Potential pitfalls Case histories Significant Guidelines/Consensus Statements References Further Reading…
8Adrenal Disorders Physiology Investigations of adrenocortical function Glucocorticoid excess Glucocorticoid deficiency Mineralocorticoid excess Mineralocorticoid deficiency Sex steroid excess Adrenal enzyme defects Sex steroid deficiency Adrenal medullary disorder Future developments Potential…
6Thyroid Disorders Embryology, anatomy, and physiology of the thyroid gland Foetal and neonatal thyroid metabolism Thyroid function tests (TFTs) Definition and classification of thyroid disorders Congenital hypothyroidism Acquired hypothyroidism Hyperthyroidism…
