John H. Sipple, MD in 1976, president of Couse Irving Memorial medical staff Introduction Multiple endocrine neoplasia type 2A (Sipple syndrome) was first described by John H. Sipple in 1961…

  Mean age of onset (years) Frequency (%) Central nervous system (CNS)   Retinal hemangioblastomas 18 70 Craniospinal hemangioblastomas 29 60–90 Endolymphatic sac tumors 22–32 11–16 Visceral    Pheochromocytomas 30 10–20…

Fig. 1 (a) Intraoperative photo of small bowel obstruction due to kinking caused by neuroendocrine tumor. (b) CT scan image demonstrating the same neuroendocrine tumor (indicated by arrow) Carcinoid Syndrome…

Robert M. Zollinger. Photograph taken for cover of Modern Medicine, May 25, 1964 Surgeons and physicians will always associate Dr. Zollinger with gastrinoma , the “Zollinger–Ellison syndrome,” which he and…

Hormones Precursor/activator Products Amines Tryptophan Serotonin 5-Hydroxytryptophan 5-HIAA Histidine Histamine Peptides Kallikrein Bradykinin Kallidin Tachykinins Substance P Neurokinin A Neurokinin B Neuropeptide K Hemokinin-1 – Motilin ACTH Chromogranin A Prostaglandins…

Dr. Allen Oldfather Whipple. (Courtesy of Samir Johna, MD) Introduction Allen Oldfather Whipple , called Oldfather by his closer friends, was born on September 2, 1881, in Oroomisha, Persia (currently…

Photograph of Cushing in his dressing room. Immediately following surgery, Cushing would illustrate the operative findings. It was common for him to wear his operative gloves while drawing these illustrations….

Dr. Charlie in scrubs To have a continuing, tangible influence on the daily activities of a large medical institution, a century and a half after its origin, and 75 years…

Professor Eugen von Hippel. (Courtesy of VHL Family Alliance) Introduction An autosomal dominant familial cancer syndrome , von Hippel–Lindau (vHL), affects numerous organs, most prominently the central nervous system (CNS;…

Fig. 1 Adrenal anatomy and blood supply Blood Supply Arteries The adrenal gland has three main groups of arteries carrying oxygenated blood to the cortex and medulla [10]. The superior…