Possible mechanisms by which pancreatic cancer could contribute to the development of type 2 diabetes include the following: (1) destruction of islets, (2) impairment of the insulin secretory mechanism, (3)…
FIGURE 29-1. A, Clinical response to leptin therapy in congenital leptin deficiency. B, Leptin therapy is associated with pulsatile gonadotropin secretion at an appropriate developmental age in child A (age…
FIGURE 38-1. Congenital lipodystrophy. Although there is a lack of consensus on the definition of the lipodystrophy syndrome(s), the diagnosis of lipodystrophy is usually made clinically and is often based…
Pituitary Development ORIGIN Phylogenetic studies in several vertebrate species led to the conclusion that the pituitary gland arises from oral epithelia. Fate-mapping experiments conducted in these animal species trace the…
PERIOPERATIVE MANAGEMENT Use of glucocorticoids to reduce peritumoral edema, cerebrospinal fluid diversion to treat hydrocephalus, anticonvulsants to prevent seizures, and hormonal replacement for patients with tumors in the hypothalamic-pituitary region…
FIGURE 6-1. Modular structure of nuclear hormone receptors. The most highly conserved domain is the DNA-binding domain, DBD, followed by the ligand-binding domain, LBD. The domains are sometimes also referred…
Hyperthyroidism in the Neonatal Period and Childhood Stephen H. Lafranchi Cheryl E. Hanna Hyperthyroidism is less common in children and adolescents than in adults, and it is rare in neonates….
Reduced Sensitivity to Thyroid Hormone: Defects of Transport, Metabolism, and Action Alexandra M. Dumitrescu Samuel Refetoff Resistance to thyroid hormone (RTH), a syndrome of reduced responsiveness of target tissues to…
Thyroid Disruptors Elizabeth N. Pearce Introduction Over the past decades, there has been increasing concern about human and wildlife exposure to endocrine disruptors, chemicals that could disrupt endogenous hormone function….
Thyroid Disorders During Pregnancy and Postpartum John H. Lazarus Jorge H. Mestman Thyroid disorders are common. The prevalence of hyperthyroidism is around 5 per 1000 and hypothyroidism about 3 per…
