Molecular Methods in Cancer
Molecular Methods in Cancer Larissa V. Furtado Jay L. Hess Bryan L. Betz APPLICATIONS OF MOLECULAR DIAGNOSTICS IN ONCOLOGY Molecular diagnostics is increasingly impacting a number of areas of cancer…
Hallmarks of Cancer: An Organizing Principle for Cancer Medicine
Hallmarks of Cancer: An Organizing Principle for Cancer Medicine Douglas Hanahan Robert A. Weinberg INTRODUCTION The hallmarks of cancer comprise eight biologic capabilities acquired by incipient cancer cells during the…
The Cancer Genome
The Cancer Genome Yardena Samuels Alberto Bardelli Jared J. Gartner Carlos López-Otin INTRODUCTION There is a broad consensus that cancer is, in essence, a genetic disease, and that accumulation of…
Topoisomerase Interactive Agents
Topoisomerase Interactive Agents Khanh T. Do Shivaani Kummar James H. Doroshow Yves Pommier CLASSIFICATION, BIOCHEMICAL, AND BIOLOGIC FUNCTIONS OF TOPOISOMERASES Nucleic acids (DNA and RNA) being long polymers, topoisomerases fulfill…
Alkylating Agents
Alkylating Agents Kenneth D. Tew PERSPECTIVES Alkylating agents were the first anticancer molecules developed, and they are still used today. After more than 50 years of use, the basic chemistry…
Cutaneous Melanoma
Cutaneous Melanoma Antoni Ribas Craig L. Slingluff Jr. Steven A. Rosenberg INTRODUCTION Melanoma arises from the malignant transformation of the melanocyte, the cell responsible for the production of the pigment…
Genetic Testing in Skin Cancer
Genetic Testing in Skin Cancer Michele Gabree Meredith L. Seidel INTRODUCTION Many hereditary cancer predisposition syndromes are associated with cutaneous findings. Identification of unique dermatologic features provides an opportunity to…
Molecular Biology of Cutaneous Melanoma
Molecular Biology of Cutaneous Melanoma Michael A. Davies Levi A. Garraway INTRODUCTION The most common forms of skin cancer are basal cell carcinoma, squamous cell carcinoma, and melanoma. While melanoma…
Cancer of the Skin
Cancer of the Skin Sean R. Christensen David J. Leffell INTRODUCTION One in five Americans will develop nonmelanoma skin cancer (NMSC) during his or her lifetime. NMSC is the most…
