Clinical Application
Clinical Application The clinical application of immunohistochemistry is discussed in Chapter 3; this chapter is devoted mainly to flow cytometric applications. By using a panel of appropriately selected monoclonal antibodies,…
Classification of Hematologic Neoplasms
Classification of Hematologic Neoplasms There are two major groups of hematologic neoplasms: Lymphoma and leukemia. Lymphoma is lymphoid tumors initially confined to lymphoid organs or extranodal tissue, whereas leukemia includes…
Molecular Genetics
Molecular Genetics Although this book is devoted mainly to immunophenotyping of hematologic neoplasms by flow cytometry and immunohistochemistry, molecular genetics is incorporated in the discussion of all our cases, as…
Principles of Immunohistochemistry
Principles of Immunohistochemistry For many years, pathologists had depended on morphology alone to make a histologic diagnosis until the availability of “special stains.” Special stains were developed because pathologists always…
Principles of Flow Cytometry
Principles of Flow Cytometry INSTRUMENTATION A flow cytometer is versatile in its capability of measuring multiple parameters simultaneously. These parameters include the physical properties of cells (e.g., cell size and…
General Introduction
General Introduction With the progress in subclassification of hematologic neoplasms and the refinement in treatment of these tumors, diagnosis of lymphoma and leukemia has become increasingly complicated. The World Health…
Paraneoplastic Endocrine Syndromes
Paraneoplastic Endocrine Syndromes Subhash Kukreja Cancer cells frequently produce peptides that are not normally synthesized by the tissue of origin. In addition, peptides that are normally produced in a paracrine…
Carcinoid Tumors
Carcinoid Tumors Nathan J. O’Dorisio Thomas M. O’Dorisio M. Sue O’Dorisio DEFINITION Neuroendocrine tumors are characterized by the production, storage, and secretion of polypeptides, biogenic amines, and, in some cases,…
Multiple Endocrine Neoplasia
Multiple Endocrine Neoplasia Glen Sizemore Norma Lopez Two sets of multiple endocrine neoplasia (MEN) syndromes and multiple tumor associations are characterized by the work of Steiner et al. [1]. Table…
