Most cases of primary aldosteronism (PA) are the results of either an aldosterone-producing adenoma or bilateral hyperplasia. Adrenocortical carcinoma (ACC) is a very rare cause of PA, accounting for <1%…
Approximately 50% of adrenocortical carcinomas (ACCs) hypersecrete adrenal steroids. When secretory, ACCs are typically plurihormonal—most commonly glucocorticoids and adrenal androgens. Rarely ACCs secrete a single steroid in excess. The case…
When a patient presents with an acute onset of severe Cushing syndrome (CS) due to metastatic adrenocortical carcinoma (ACC), clinicians ask: “Should the primary tumor be resected?” This is a…
Adrenocortical carcinoma (ACC) presents with overt symptoms of hormone excess (usually androgen, cortisol, or combined hypersecretion) in 30%–40% of cases. Notably, even patients with incidentally discovered ACC or those presenting…
Adrenocortical carcinoma (ACC) can present with overt symptoms of hormone excess (usually androgen, cortisol, or combined hypersecretion) in 30%–40% of cases. Imaging characteristics include unenhanced attenuation >20 Hounsfield units (HU),…
The Weiss scoring system is the most popular system used in the histologic diagnosis of adrenocortical carcinoma (ACC) and includes assessment of diffuse architecture; clear cells; nuclear grade; mitotic rate;…
Adrenal “incidentaloma” is frequently ignored by clinicians. However, approximately 50% of all patients with adrenocortical carcinomas (ACCs), pheochromocytomas, and overt hormone excess are discovered incidentally. When imaging characteristics of the…
When a patient is incidentally discovered with an adrenal mass, two questions need to be answered: (1) Is the adrenal mass malignant? (2) Is the adrenal mass hormonally active? Age,…
Carney triad (described in 1977) is a rare, nonfamilial, multitumoral syndrome, with three tumors in the initial description: gastrointestinal stromal tumor (GIST), pulmonary chondroma, and extraadrenal paraganglioma. Subsequently, two other…
Symptoms of overt glucocorticoid excess should prompt appropriate biochemical and imaging workup. In this case, despite imaging characteristics of myelolipoma and contralateral adrenal gland without abnormalities, ipsilateral adrenal adenoma was…
