Hormonal Agents
Hormonal Agents Matthew P. Goetz Charles Erlichman Charles L. Loprinzi Manish Kohli INTRODUCTION Hormonal agents are commonly used as a treatment of hormonally responsive cancers, such as breast, prostate, or…
Miscellaneous Chemotherapeutic Agents
Miscellaneous Chemotherapeutic Agents M. Sitki Copur Scott Nicholas Gettinger Sarah B. Goldberg Hari A. Deshpande HOMOHARRINGTONINE AND OMACETAXINE Homoharringtonine and its congener, harringtonine, are cephalotaxine esters isolated from the evergreen…
Poly (ADP-ribose) Polymerase Inhibitors
Poly (ADP-ribose) Polymerase Inhibitors Alan Ashworth INTRODUCTION Cancer cells may harbor defects in DNA repair pathways leading to genomic instability. This can foster tumorigenesis but also provides a weakness that…
Proteasome Inhibitors
Proteasome Inhibitors Christopher J. Kirk Brian B. Tuch Shirin Arastu-Kapur Lawrence H. Boise BIOCHEMISTRY OF THE UBIQUITIN-PROTEASOME PATHWAY The ubiquitin proteasome system is involved in the degradation of more than…
Histone Deacetylase Inhibitors and Demethylating Agents
Histone Deacetylase Inhibitors and Demethylating Agents Steven D. Gore Stephen B. Baylin James G. Herman INTRODUCTION The past decade has seen an explosive growth, especially at a genome-wide level, in…
Kinase Inhibitors as Anticancer Drugs
Kinase Inhibitors as Anticancer Drugs Charles L. Sawyers INTRODUCTION In 2001, the first tyrosine-kinase inhibitor imatinib was approved for clinical use in chronic myeloid leukemia. The spectacular success of this…
Antimicrotubule Agents
Antimicrotubule Agents Christopher J. Hoimes Lyndsay N. Harris MICROTUBULES Microtubules are vital and dynamic cytoskeletal polymers that play a critical role in cell division, signaling, vesicle transport, shape, and polarity,…
Topoisomerase Interactive Agents
Topoisomerase Interactive Agents Khanh T. Do Shivaani Kummar James H. Doroshow Yves Pommier CLASSIFICATION, BIOCHEMICAL, AND BIOLOGIC FUNCTIONS OF TOPOISOMERASES Nucleic acids (DNA and RNA) being long polymers, topoisomerases fulfill…
Antimetabolites
Antimetabolites M. Wasif Saif Edward Chu ANTIFOLATES Reduced folates play a key role in one-carbon metabolism, and they are essential for the biosynthesis of purines, thymidylate, and protein biosynthesis. Aminopterin…
Platinum Analogs
Platinum Analogs Peter J. O’Dwyer A. Hilary Calvert INTRODUCTION The platinum drugs represent a unique and important class of antitumor compounds. Alone or in combination with other chemotherapeutic agents, cis-diamminedichloroplatinum…
