Although adrenocortical nodularity is fairly common in patients with multiple endocrine neoplasia type 1 (MEN-1), adrenocortical carcinoma (ACC) is rare. The case presented herein is a cautionary notice for clinicians…
Most cases of adrenocortical carcinoma (ACC) are sporadic; however, some occur as a part of a hereditary syndrome, such as Li-Fraumeni syndrome, multiple endocrine neoplasia type 1, familial adenomatous polyposis,…
Most cases of primary aldosteronism (PA) are the results of either an aldosterone-producing adenoma or bilateral hyperplasia. Adrenocortical carcinoma (ACC) is a very rare cause of PA, accounting for <1%…
Approximately 50% of adrenocortical carcinomas (ACCs) hypersecrete adrenal steroids. When secretory, ACCs are typically plurihormonal—most commonly glucocorticoids and adrenal androgens. Rarely ACCs secrete a single steroid in excess. The case…
When a patient presents with an acute onset of severe Cushing syndrome (CS) due to metastatic adrenocortical carcinoma (ACC), clinicians ask: “Should the primary tumor be resected?” This is a…
Adrenocortical carcinoma (ACC) presents with overt symptoms of hormone excess (usually androgen, cortisol, or combined hypersecretion) in 30%–40% of cases. Notably, even patients with incidentally discovered ACC or those presenting…
Adrenocortical carcinoma (ACC) can present with overt symptoms of hormone excess (usually androgen, cortisol, or combined hypersecretion) in 30%–40% of cases. Imaging characteristics include unenhanced attenuation >20 Hounsfield units (HU),…
The Weiss scoring system is the most popular system used in the histologic diagnosis of adrenocortical carcinoma (ACC) and includes assessment of diffuse architecture; clear cells; nuclear grade; mitotic rate;…
Adrenal “incidentaloma” is frequently ignored by clinicians. However, approximately 50% of all patients with adrenocortical carcinomas (ACCs), pheochromocytomas, and overt hormone excess are discovered incidentally. When imaging characteristics of the…
When a patient is incidentally discovered with an adrenal mass, two questions need to be answered: (1) Is the adrenal mass malignant? (2) Is the adrenal mass hormonally active? Age,…
