Pediatric Renal Tumors
Chapter Outline PATHOLOGY OF PEDIATRIC RENAL TUMORS Staging Wilms Tumor (Nephroblastoma) Clear Cell Sarcoma of the Kidney Congenital Mesoblastic Nephroma Malignant Rhabdoid Tumor of the Kidney Renal Carcinomas in Children…
Neuroblastoma
Chapter Outline EPIDEMIOLOGY PATHOGENESIS Embryology Development of the Sympathetic Nervous System Genetic Disorders Associated with Neuroblastoma Neuroblastoma Stem Cells Hereditary Predisposition to Neuroblastoma Genetic Aberrations in Sporadic Neuroblastoma Chromosomal Abnormalities…
Hematologic Manifestations of Systemic Diseases
Chapter Outline COLLAGEN DISORDERS Collagen Vascular Disease Vasculitis Connective Tissue Disorders INFECTIOUS DISEASES General Hematologic Signs of Infection Hematologic Aspects of Specific Infections CARDIAC DISEASE Hemolysis Acquired Coagulation Abnormalities Platelet…
Cancer Chemotherapy for Pediatric Patients
Chapter Outline CHEMOTHERAPEUTIC AGENTS CLINICAL APPLICATION OF CHEMOTHERAPY CHEMOTHERAPY IN CHILDREN PHARMACOKINETIC CHANGES DURING CHILDHOOD Absorption Volume of Distribution Hepatic Metabolism Renal and Hepatic Excretion Influence of Underlying Disease on…
Acute Lymphoblastic Leukemia
Chapter Outline CLASSIFICATION Morphologic and Cytochemical Classification Immunophenotype MOLECULAR PATHOGENESIS Transcriptional Regulators Growth Factor Signaling Molecular Pathogenesis of Select High-Risk Subtypes CLINICAL MANIFESTATIONS Peripheral Blood Bone Marrow Extramedullary Leukemia DIFFERENTIAL…
Informatics
Chapter Outline DNA-BASED METHODS Comparative Genomic Hybridization Genotyping Capillary (Sanger) Sequencing Pyrosequencing DNA Microarrays Single Nucleotide Polymorphism Arrays Chromatin Immunoprecipitation, ChIP-Chip, ChIP-Seq Genome-Wide Association Studies Exome Sequencing/Targeted Sequencing Whole Genome…
Pediatric Lymphoma
Chapter Outline LYMPHADENOPATHY Approach to the Patient EMERGENCIES IN PATIENTS WITH NEWLY DIAGNOSED LYMPHOMA HODGKIN LYMPHOMA Classic Hodgkin Lymphoma Nodular Lymphocyte-Predominant Hodgkin Lymphoma Treatment of Relapsed Hodgkin Lymphoma Late Effects…
Immune Response
Chapter Outline LYMPHOCYTE DEVELOPMENT LYMPHOCYTE SPECIFICITY B-CELL ONTOGENY Immunoglobulin Structure Immunoglobulin Rearrangement and B-Cell Maturation in Bone Marrow Peripheral B-Cell Maturation and Differentiation T-CELL ONTOGENY T-Cell Receptor Subtypes and Specificity…
Targeted Therapies in Oncology
Chapter Outline TRADITIONAL CHEMOTHERAPY Conventional Chemotherapeutic Approaches: Not Entirely Nonspecific Lessons Learned from Cytotoxic Chemotherapy Shortcomings of Cytotoxic Chemotherapy INTRODUCTION TO TARGETED THERAPY What is Targeted Therapy? Advantages of Targeted…
Origins and Evolution of Pediatric Cancers
Chapter Outline PEDIATRIC VERSUS ADULT CANCERS CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA AS A MODEL OF CLONAL EVOLUTION EVOLUTIONARY PENETRANCE OF DISEASE EVOLUTIONARY DYNAMICS AND CLINICAL OUTCOME “Nothing in biology makes sense…
