Informatics in Radiation Oncology
Fig. 5.1 With each step along the process, more information is created and collected which is associated with the patient The imaging data, accompanied by identifiers, is then transferred to…
Image-Based Motion Correction
Fig. 12.1 Cast the gating problem (a) into a binary classification problem (b) (Reprint from Cui et al. [2]) One major issue with learning from images is the large dimensionality…
Treatment Delivery Validation
Fig. 15.1 (a) The average chart for the clinical case. Subgroup size of four is used to verify the constancy of the flatness and symmetry. (b) The range chart of…
What Is Machine Learning?
Fig. 1.1 Categories of machine learning algorithms according to training data nature From a concept learning perspective, machine learning can be categorized into transductive and inductive learning [27]. Transductive learning…
State of Metal-Based Drugs for the Efficient Therapy of Lung Cancers and Lung Metastases
Fig. 1 Platinum complexes which entered clinical trials While most of the platinum drugs have to be administered intravenously, Satraplatin (8) was the first orally applicable platinum agent under clinical…
Cancer Statistics
Fig. 1 Lung cancer incidence and mortality rates by sex and age, United States, 2006–2010. Rates are per 100,000 and age-adjusted to the 2000 U.S. standard population During 2006–2010, the…
Lung Cancers in the Era of Targeted Therapy
Fig. 1 KRAS signaling. KRAS acts to integrate external signals from extracellular ligands that bind transmembrane growth factor receptors. The KRAS protein is localized to the cell membrane via farnesylation…
of Resistance to EGFR Tyrosine Kinase Inhibitors and Therapeutic Approaches: An Update
Drug name Generic name Target Status Reversible ZD1839 Gefitinib EGFR Approved OSI776 Erlotinib EGFR Approved BPI-2009H Icotinib EGFR Approved TAK-165 Mubritinib EGFR/ERBB2 Phase I XL647 NA EGFR/ERBB2/FLT-4 Phase II…
Cancer in Never Smokers
Risk factor Risk ratio Comments References Second hand smoke 1.34 Prospective nested case control in Europe [27] 1.23 (spouse) 1.27 (workplace) Pooled analysis from two case controls US & Europe…
