The Multidisciplinary Management of Early-Stage Thoracic Esophageal Cancer
Reference Year Path Arm N OS MS pCR RT Chemo [33] 1988–1991 SCC 100 % S CRT 45 41 3y 14 % 3y 19 % NS 11 m 10.5 m…
Principles of Radiation Therapy
Study No. of patients Radiation dose (Gy) Chemotherapy 2-year survival (%) Araujo et al. [44] 28 50 None 22 31 50 5-FU, MMC, Bleo 38 Smith et al. [45] 62…
Cellular and Molecular Biology of Esophageal Cancer
Fig. 2.1 Histological features of esophageal cancer prepared by formalin fixation and paraffin embedding reveal a well-differentiated squamous cell carcinoma with good histological detail In recent years, the use of…
Systemic Treatment for Metastatic or Recurrent Disease
Study Design N RR (%) PFS (months) OS (months) References Cisplatin-based combinations CF vs. C Phase II 88 35 vs. 19 TTP: 27 vs. 18 weeks 2 years: 18 vs….
The Multidisciplinary Management of Early Distal Esophageal and Gastroesophageal Junction Cancer
Treatment Histology No. of patients R0 resection rate Pathologic CR rate Survival Local failure References Median Overall Periop ECF + surgery Adeno 250 69 % 0 % 24 months 5 years 36 %…
Principles and Approaches in Surgical Resection of Esophageal Cancer
© Springer International Publishing Switzerland 2015Nabil F. Saba and Bassel F. El-Rayes (eds.)Esophageal Cancer10.1007/978-3-319-20068-2_9 9. Principles and Approaches in Surgical Resection of Esophageal Cancer Nabil Pierre Rizk1 (1) Thoracic Surgery, Memorial Sloan Kettering Cancer Center, New York,…
Chemoprevention for Esophageal Carcinoma
Benefits Risks Reduced cardiovascular risk (RR approx. 0.75) Increased risk of GI hemorrhage (<100 mg/day 0.3 %/year vs. 1.1 % with >325 mg/day) Reduced risk of GI cancers Increased risk…
Epigenetic of Retinoic Acid Receptor β2 Gene in Breast Cancer
Fig. 11.1 Histone acetylation. HA Histone acetylation, HAT Histone acetyltransferases, HDAC Histone deacetylases 11.1.4 Histone Methylation Histone Methylation (HM) also occurs at lysine-(K) and arginine-(R) residues without changing the chromatic…
Methylation in Colorectal Cancer
Fig. 13.1 Principle of array comparative genome hybridization (aCGH) Prominent African-Americans aberrations were chromosome X amplification in men and deletions in chromosomes 4, 8, and 18. In African-Americans several CAN…
Fundamental Aspects of Epigenetic in Cancer
Fig. 1.1 Illustration of the different molecular processes involved in epigenetic mechanisms. (From Qiu 2006; with kind permission of the publisher) . In mammals, DNA methylation stably alters the gene…
