PATHOGENESIS From a histologic point of view, two types of nodules (Figs. 82-1 and 82-2) may be discerned: a monoclonal and a polyclonal type. Studer and his group developed the…
FIGURE 126-1. The acquisition, storage and trafficking of cholesterol in steroidogenic cells. ACAT1, acylcoenzyme A cholesterolacyl transferase 1; FFA, free fatty acid; HMG-CoA, 3-hydroxy-3-methylglutaryl-coenzyme A; HDL, high-density lipoprotein; LDL, low-density…
FIGURE 104-1. Combined fetal adrenal weights according to gestational age. (Data from Young MC, Laurence KM, Hughes IA: Relationship between fetal adrenal morphology and anterior pituitary function, Horm Res 32:130–135,…
FIGURE 144-1. Formation of the morula with production of human chorionic gonadotropin (hCG), the first signal to the mother of the presence of pregnancy. As cell division occurs, hCG production…
FIGURE 108-1. Genetic causes of mineralocorticoid deficiency. The schematic cell represents a renal cell from the distal tubule/collecting duct segment, which expresses the mineralocorticoid receptor (MR), is aldosterone (A) sensitive,…
FIGURE 140-1. Diagrammatic representation of sources of androgen and estrogen and the physiology of their actions. Most testosterone and approximately 15% of estradiol are secreted directly by the testes. Both…
FIGURE 127-1. Activation of steroid receptors. In the absence of ligand, steroid receptors (SR) reside in an inactive complex containing heat shock proteins (HSP) and other proteins. Upon steroid binding,…
FIGURE 7-1. Genes and polymorphic marker density of chromosome 8. The relative numbers of genes and SNPs are shown above chromosome 8. The microsatellite markers (short tandem repeats, STRs) and…
FIGURE 50-1. Combined pancreas and kidney transplant. Digestive juices of the pancreas are drained into the intestine via an enteric anastomosis between the donor duodenum and the recipient ileum. Venous…
FIGURE 24-1. Structure of the human insulin-like growth factor 1 (IGF1) gene and the precursor proteins it encodes. The black boxes that are shown represent exons. The portions of each…
