Fig. 11.1 Atypical femur fracture treated with intramedullary nail showing sclerotic margins consistent with nonunion Complete fractures are treated most commonly with intramedullary devices; more proximal fractures that are difficult…
Fig. 2.1 Structures of major bisphosphonates used clinically Bisphosphonates have been used since the 1970s across the whole spectrum of bone resorption disorders , including Paget’s disease and cancer-related bone…
Fig. 1.1 Electron micrograph of damaged trabecula . A microcrack is present. Fibrillar structures can be observed spanning the crack as fibrils have been pulled apart from each other. From…
Fig. 8.1 ASBMR-esta blished AFF criteria and schematic with radiograph illustrating the major features of AFFs The incidence of AFFs is very low [8], especially when compared to the number…
Study Drug Duration (months) N Age (years) Distal radius Tb.vBMD or BV/TV Distal radius Ct.vBMD Distal radius Ct.Th Burghardt et al. (2010) Alendronate 24 13 56 ± 4 NS NS NS Placebo…
Year [ref.] Design Subjects Measurements Factors identified Odds ratio/subhazard ratio (95 % CI) 2012 [63] Cross-sectional study 179 postmenopausal women Bone turnover markers DXA Femur structure Fractal analysis Prior fracture…
© Springer International Publishing Switzerland 2016Stuart Silverman and Bo Abrahamsen (eds.)The Duration and Safety of Osteoporosis Treatment10.1007/978-3-319-23639-1_23 23. Conclusions Stuart L. Silverman1 and Bo Abrahamsen2 (1) Division of Rheumatology, Cedars-Sinai Medical Center, UCLA School of Medicine and the…
Medication Short-term issues Long-term issues Comments Estrogena Decreased hot flashes; breast tenderness Venous thromboembolism; stroke Benefit/risk most favorable in younger postmenopausal women; different estrogen preparations may have different clinical profiles…
Medication Adverse event Magnitude of association (from pooled analysis of clinical data)a Bisphosphonates Possible association with atypical subtrochanteric fractures of the femur Not available—but the risk for this type of…
© Springer International Publishing Switzerland 2016Stuart Silverman and Bo Abrahamsen (eds.)The Duration and Safety of Osteoporosis Treatment10.1007/978-3-319-23639-1_20 20. Other Safety Concerns Michael R. McClung1 (1) Oregon Osteoporosis Center, 25 NW 23rd Place, Suite 6 #175, Portland, OR 97210,…
