in the Elderly
Class^ Median overall survival (months) 2-year survival (%) 1 58 76 2 37 68 3* 18 35 4* 11 15 5* 9 6 6* 4.5 4 Legend ^Class defined by…
Therapy of Glioblastoma
Trial Patients (% GBM) Treatment Med. survival (months) P value BTSG 66-01 [4] 96 (85 %) No radiotherapy 3.5 <0.05 WBRT < 5000 cGy 7.7 WBRT ≥ 5000 cGy 8.4 BTSG 69-01 [3] 222 (90 %) No radiotherapy…
for Malignant Gliomas
Trial Vaccine Type Phase Experimental design N PFS (mo) OS (mo) NCT00612001 [32] DC I Autologous DC + selected glioma antigens 6 9.6 18.1 NCT00846456 [59] DC I/II Autologous DC transfected with…
Chemotherapeutic Approaches in Adult High-Grade Gliomas
Fig. 1 Schematic representing select targeted therapies for which clinical trial results are available in high-grade gliomas. Edited with permission from Lee et al. “current and future directions for Phase II…
Medical Treatment of Glioblastoma
Study (reference) Number of patients Treatment arms PFS (months) OS (months) Comments EORTC/NCI [1] 573 RT/TMZ versus RT 6.9 versus 5.0 15 versus 12 RT/TMZ superior to RT alone RTOG…
of Anaplastic Glioma
Fig. 1 A schematic overview on the current molecularly based subgrouping. In addition to the standard treatments, radiotherapy (RT), temozolomide (TMZ), procarbazine, lomustine and vincristine (PCV) or radiochemotherapy, there are trials…
Other Carcinomas
Fig. 19.1 Incidence of invasive head and neck cancer in AYAs (age 15–39), 2000–2011, SEER18, by anatomical site 19.1.1 Incidence Figure 19.2 shows the incidence of head and neck (oropharyngeal;…
Cancer Incidence, Survival, and Mortality Among Adolescents and Young Adults
Age 15–39 Estimated cases a Incidence rate Estimated deaths Death rate All cancers 1,048,821 37.5 390,579 14.0 Males 383,209 26.8 183,116 12.8 Females 665,612 48.7 207,463 15.2 LDRb 807,768 33.8…
Cancer of the Kidney, Bladder, and Prostate
Fig. 17.1 Incidence of renal cell carcinoma by age, sex (left panel), and extent of disease (right panel) at diagnosis, 2000–2011, SEER18. The left panel inset has a log scale…
