Chapter 5 – Hyperplasia
Abstract Bone marrow (BM) hyperplasia, a non-neoplastic expansion of one or more of the haematopoietic cell lineages due to an increased number of cells, can manifest in a range of…
Chapter 11 – Myelodysplastic/Myeloproliferative Neoplasms
Abstract The myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are clonal myeloid neoplasms characterized at the time of their initial presentation by the simultaneous presence of myelodysplastic and myeloproliferative features, which prevent them from…
Chapter 9 – Acute Myeloid Leukaemia
Abstract Acute myeloid leukaemia (AML) is a highly complex and heterogeneous disease. Proper classification according to the 2016 World Health Organization (WHO) classification requires a systematic approach and integration of…
Chapter 8 – Myelodysplastic Syndromes
Abstract Myelodysplastic syndromes (MDS) comprise a heterogeneous group of myeloid neoplasms defined by peripheral cytopaenia, morphologic dysplasia in one or more haematopoietic lineages, and genetic instability with risk of transformation…
Chapter 10 – Myeloproliferative Neoplasms
Abstract The ‘classical’ Philadelphia chromosome-negative myeloproliferative neoplasms (MPN), essential thrombocythaemia (ET), primary myelofibrosis (PMF) and polycythaemia vera (PV), are characterized by clonal myeloproliferation with effective maturation causing accumulation of terminally…
Chapter 7 – Malignant Disorders of the Histiocytic/Dendritic Lineage
Abstract Disorders of histiocytic and dendritic cell origin, traditionally referred to as histiocytoses [1], form a group of extremely rare tumours, characterized by variable malignant potential and unpredictable clinical course,…
Chapter 3 – Necrosis, Stromal Changes and Artefacts
Abstract The bone marrow (BM) extracellular matrix (ECM) is often inconspicuous, and hence neglected in a normal BM trephine biopsy (BMB), but it has essential functions in the homeostasis of…
Chapter 4 – Aplasia
Abstract Aplasia is a pathologic term that is broadly defined as the absence or near-absence of one or more haematopoietic lineages in the bone marrow (BM). Clinically, BM aplasia affecting…
Chapter 1 – The Bone Marrow Biopsy
Abstract Trepanning of the bone is one of the oldest known procedures carried out by man and the use of the modern trephine biopsy has a venerable history. Parapia has…
Chapter 2 – The Normal Bone Marrow
Abstract Knowledge and understanding of the appearance of normal bone marrow (BM) and therefore normal haematopoiesis is essential for both general pathologists and specialist haematopathologists. It is only once normal…
