Chapter Outline TECHNICAL CONSIDERATIONS Conventional Radiography Ultrasound Computed Tomography Magnetic Resonance Imaging Nuclear Medicine STAGING CONSIDERATIONS CENTRAL NERVOUS SYSTEM TUMORS Supratentorial Tumors Midline Supratentorial Tumors Infratentorial Tumors PULMONARY AND INTRATHORACIC…
Chapter Outline EPIDEMIOLOGY NEURODEVELOPMENT Neural Tube Development of Brain Structures Cancer Stem Cells Genetic and Signaling Pathways Implicated in Development and in Pediatric Tumors CONCEPTUAL ORGANIZATION OF PEDIATRIC BRAIN TUMORS…
Chapter Outline EPIDEMIOLOGY PRESENTATION AND EVALUATION STAGING AND GRADING TREATMENT Local Control Chemotherapy GENERAL BIOLOGIC FEATURES ADIPOCYTIC TUMORS FIBROBLASTIC AND MYOFIBROBLASTIC TUMORS Desmoid Tumor Infantile Myofibroma/Myofibromatosis and Hemangiopericytoma Infantile Fibrosarcoma…
Chapter Outline CYTOGENETIC AND MOLECULAR METHODOLOGIES Karyotyping Molecular Cytogenetics Polymerase Chain Reaction–Based Molecular Assays Array Comparative Genomic Hybridization and Single Nucleotide Polymorphism Profiling Assays Next-Generation Sequencing and Other Techniques GENOMIC…
Chapter Outline DEVELOPMENT OF THE GERMLINE Specification of Primordial Germ Cells Primordial Germ Cell Migration Erasure of Imprinting Gonadogenesis HISTOPATHOLOGY OF GERM CELL TUMORS Overview of Testicular Germ Cell Tumors…
Carlo Brugnara APPENDIX 1 Hematologic Values * in Normal Fetuses at Different Gestational Ages Week of Gestation Hemoglobin (g/dL) RBCs (×10 6 /mL) Hematocrit (%) Mean Corpuscular Volume (fL) Total WBCs…
Chapter Outline OROPHARYNGEAL CANCER NASOPHARYNGEAL CARCINOMA Epidemiology Presentation Staging and Evaluation Treatment THYROID CARCINOMA Epidemiology Pathology and Molecular Pathology Clinical Presentation and Staging Treatment and Outcome BREAST TUMORS PULMONARY TUMORS…
Chapter Outline ANTERIOR MEDIASTINAL MASSES Definition Clinical Presentation Evaluation and Imaging Treatment Conclusions SPINAL CORD COMPRESSION Clinical Presentation Evaluation and Imaging Treatment Late Effects HYPERLEUKOCYTOSIS AND LEUKOSTASIS Definition Pathogenesis Clinical…
Chapter Outline HISTORIC PERSPECTIVE WHAT IS “CONSENT” IN PEDIATRICS? ASSENT IN CHILDHOOD CANCER TRIALS PEDIATRIC CLINICAL TRIALS Minimal Risk Phase I and II Trials in Pediatric Oncology Phase III Trials…
Chapter Outline EPIDEMIOLOGY ETIOLOGY CLINICAL PRESENTATION AND EVALUATION Clinical Manifestations Radiologic Evaluation Biopsy Laboratory Evaluation PATHOLOGY AND STAGING Pathology Staging NATURAL HISTORY AND PROGNOSIS Localized Disease Metastatic and Relapsed Disease…
