Fig. 23.1 Clinical appearance of retinoblastoma. A large retinoblastoma before (left) and after (right) chemotherapy. Note the marked reduction in tumor size after chemotherapy. This view was obtained with a…
Mutation Description Missense A change in one DNA base pair that results in the substitution of one amino acid Nonsense A change in one DNA base pair that results in…
Tumor type Cytogenetic finding Molecular trace Reference Ewing sarcoma t(11;22)(q24;q12) EWSR1-FLI1 Delattre et al. [100] t(21;22)(q22;q12) EWSR1-ERG Sorensen et al. [240] t(19;der(ins.inv(21;22))) EWSR1-ERG Maire et al. [241] t(16;21) (p11;q22) FUS-ERGa…
Name Frequency (%) Morphological features of well differentiated lesions Segment of the reproductive tract with similar features Serous 50 Columnar cells with a prominent ciliated border that often form finger-like…
Fig. 32.1 The histology of conventional and HPV-associated head and neck squamous cell carcinomas (HNSCC). (a) A well differentiated conventional type HNSCC with keratinization (hematoxylin-eosin, 100×). (b) HPV-associated HNSCC which…
White African Americans Asian American and Pacific Islander American Indian and Alaska Native Hispanic/Latino (a) Incidence Males 58.2 68.4 44.1 38.1 50 Females 42.6 51.7 33.1 30.7 35.1 (b)…
Fig. 18.1 Scanning electron microscopy (SEM) micrographs showing the morphology of erionite fibers, crocidolite asbestos, and chrysotile fibers. (a) Erionite f ibers from Pine Valley, NV (courtesy of Dr. Ian…
Diagnosis Cytogenetic change Molecular change Additional changes Chronic myeloid leukemia t(9;22)(q34;q11) 210KD BCR-ABL CML-AP/BP t(9;22)(q34;q11) 210KD BCR-ABL +8, +Ph, +19, i(17q), t(3;21)(q26;q22) Polycythemia vera JAK2V617F (>90%) +8, +9, del(20q),…
Fig. 37.1 Epidermal growth factor receptor structural and functional domains . (a) Schematic representation of EGFR sequence. L and CR, ligand-binding and cysteine-rich domains, TM transmembrane domain, TK tyrosine kinase…
Fig. 10.1 In cell culture systems, cellular senescence is described as a decrease in proliferative capacity and eventual cessation of proliferation with increasing number of population doublings (PDs). This property…
