Fig. 16.1 Fundoscopic examination of a patient with Waldenström’s macroglobulinemia demonstrating hyperviscosity-related changes including dilated retinal vessels, peripheral hemorrhages, and “venous sausaging” (Courtesy of Marvin Stone M.D.) 16.3.2 Immunophenotype The…
Fig. 14.1 Path slides to be chosen by pathologist Other cytogenetic abnormalities that have been reported in MALT lymphomas include t(11;18), t(14;18), t(1;14), t(3;14), and trisomy 8. The translocation t(11;18)…
Fig. 17.1 Blood smear of a B-cell prolymphocytic leukemia. An 84-year-old man presented with abdominal pain to the emergency room with a WBC of 140,000 and splenomegaly. There is marked…
Martin Dreyling and Michael E. Williams (eds.)Hematologic MalignanciesRare Lymphomas201410.1007/978-3-642-39590-1_4 © Springer-Verlag Berlin Heidelberg 2014 4. Signaling Pathways in Rare Lymphomas Andrew Lipsky1, Patricia Pérez-Galán3, Claudio Agostinelli4, Pier Paolo Piccaluga4, Stefano A. Pileri4 and Adrian Wiestner2 (1) Department of Internal Medicine, Montefiore Medical Center,…
Author (year) n PFS OS SMZL Thieblemont et al. (2002) 81 Presence of M-component Beta2 microglobulin ≥3 mg/L Presence of animmunological event Leukocytes ≥20 109/L Lymphocytosis ≥9 109/L Presence of…
Fig. 6.1 (a and b) ALCL, ALK- with large tumor cells containing pleomorphic nuclei 6.3 Immunophenotype The tumor cells of ALCL, ALK-positive and ALK-negative, universally express CD30 and a majority…
Mature leukemias • T-cell prolymphocytic leukemia • T-cell large granular lymphocytic leukemia • Chronic lymphoproliferative disorders of NK-cells • Aggressive NK-cell leukemia • Adult T-cell leukemia/lymphoma • Sezary syndrome Mature…
Fig. 1 A Performance of the Lymph2Cx assay using an abbreviated gene set (20 genes) compared to the “gold standard method” of previously reported GEP as well as three IHC-based algorithms…
Prognostic group # risk factorsa Low risk 0, 1 Low intermediate 2 High intermediate 3 High 4, 5 aelevated LDH, advanced stage (Ann Arbor III/IV), age > 60, ≥ 2 extralymphatic sites of involvement…
Fig. 1 a Kaplan–Meier curve showing progressive improvement in the overall survival of FL patients over time. b Patients diagnosed and treated in post-rituximab era-2 (light color) had a statistically significant…
