html xmlns=”http://www.w3.org/1999/xhtml”> 52 Cancer Immunotherapy with Vaccines and Checkpoint Blockade Drew Pardoll Therapeutic vaccination for cancer continues to be a major approach to the overall immunotherapy of cancer. Historically, interest…
Figure 42-1 Development of melanoma Although melanomas can develop from melanocytes at the epidermal-dermal junction directly or in a preexisting nevus, an orderly progression from melanocyte to neoplasm (benign nevus)…
Figure 15-1 Senescence stimuli and biological characteristics Senescence is induced by diverse endogenous and exogenous stresses that promote strong pro-proliferative signaling and DNA damage responses. Senescent cells undergo a permanent…
A third interpretation of the role of haploinsufficiency in tumorigenesis is based on the exquisite sensitivity of cells to even small changes in the levels of some cancer-associated proteins. Thus,…
html xmlns=”http://www.w3.org/1999/xhtml”> 53 Interferons Ernest C. Borden ∗ Introduction Interferons (IFNs) comprise a family of secreted α-helical cytokines induced in response to specific extracellular biomolecules through stimulation of Toll-like receptors…
html xmlns=”http://www.w3.org/1999/xhtml”> 49 Pharmacogenomics Peter H. O’Donnell and Mark J. Ratain Introduction The term pharmacogenetics is believed to have first been used in 1959 by Vogel who defined it as…
This table is not comprehensive, but provides an example of breast cancer multiplexed gene tests that are currently in development or have been commercialized. The type of sample, number of…
Unlike tumor cells with PTEN loss, tumor cells that have lost TSC function are generally less belligerent. It is now accepted that this is due to negative feedback loops that…
html xmlns=”http://www.w3.org/1999/xhtml”> 22 Protein Biomarkers for Detecting Cancer Molecular Screening Susan Fisher and H. Ewa Witkowska No matter how many mistakes you make or how slow you progress, you are…
Figure 21-1 Biomarkers in cancer etiology Biomarkers in cancer etiologic studies can be classified into three broad categories: biomarkers of exposure, biomarkers of effect, and biomarkers of susceptibility. Biomarkers of…
