Figure 8.1 Toe melanoma A 4 mm punch biopsy was taken under local anesthetic digital block. Histology was reported as ‘invasive malignant melanoma with Breslow thickness of at least 1.2…
Figure 9.1 Preoperative Halo graft markings The skin graft is harvested from the ‘halo’ area i.e., the outer area geometrically called the annulus as shown. I use a No. 22…
Figure 2.1 Large lateral nasal defect The skin graft was ‘quilted’ in place with a quilting suture through the base of the wound (Fig. 2.2). This method allows me to…
Figure 16.1 Elderly Caucasian male with large eroded lesion on the neck Differential Diagnosis Basal cell carcinoma Squamous cell carcinoma Amelanotic melanoma Keratoacanthoma Sebaceous carcinoma Merkel cell tumor Biopsy Results…
Figure 12.1 H&E, 20× magnification Figure 12.2 H&E, 100× magnification This feature creates a well-know pitfall that may happen in a limited sample of a granular cell tumour. One can…
Figure 11.1 Box shows area of application of Aldara for s BCC Histological report is detailed above – which reveals a non-ulcerated tumor of 0.8 mm Breslow thickness, Clark Level…
Fig. 1 The balance of DNA damage and DNA repair determines the stability of a genome It is becoming more and more apparent that the fine tuning of genomic stability is…
Wild-type Aneuploid strains Method Notes Haploid (1n)16 chr Monosomies (n − 1) Centromere silencing (CS) Inviable Disomies (n + 1) CS, Chromosome transfer (CT) and meiois of 3n or 5n (RM) 12 disomes from…
Fig. 1 Numbers of somatic structural variants (SV) and single nucleotide variants (SNVs) identified in prostate (Berger et al. 2011) and colorectal cancer (Bass et al. 2011) Insight into structural genomic…
Fig. 1 Telomere-DNA is an evolutionarily conserved GT-rich repetitive sequence. Basically all eukaryotes use GT-rich repetitive sequences at the ends of their chromosomes (telomeres). Despite considerable variation in telomere length and…
