Oncohema Key

Fig. 4.1 (a) Schematic representation of the structure of the human glucocorticoid receptor (hGR) gene. Alternative splicing of the primary transcript gives rise to the two mRNA and protein isoforms,…

References No. cases Prevalence (%) Measurement Criteria for hypertension (mmHg) Nabarro [123] 256 30.5 Clinical Not known Rodrigues et al. [24] 34 26 Clinical 160/95 Kraatz et al. [23] 158…

Unilateral forms of PA (surgically treatable) Aldosterone-producing adenoma 30–40% Unilateral adrenal hyperplasia <5% Aldosterone-producing carcinoma Rare Bilateral forms of PA (medically treated) Bilateral adrenal hyperplasia 60–70% Familial hyperaldosteronism type I…

Fig. 11.1 The frailty cycle. Modified from ref. [21] Such chronic diseases are mainly atherosclerosis, diabetes mellitus, and obesity. Thus, in view of the multifactorial origin of aging symptoms, effects…

Fig. 13.1 Putative mechanisms for development of obesity-hypertension (OH) Table 13.1 Mechanical and humoral factors implicated in OH Hyperinsulinemia and insulin resistance Chronic noninfective inflammation Chronic adipocytokinemia (elevated local adipose…

Common conditions with low renin concentrations Mineralocorticoid excess  Primary aldosteronism (see Chap. 1)  Cushing’s Syndrome (see Chap. 3)  Glucocorticoid/cortisol resistance (see Chap. 4)  Apparent mineralocorticoid excess syndrome  Licorice or carbenoxolone…

Fig. 6.1 Computerized tomography of a benign adrenocortical adenoma of the left adrenal (arrow). Reprinted with permission from Androulakis et al. [19] Arterial hypertension (AH) is a prevailing, but not…

Gastrointestinal factors: Insufficient oral intake Malabsorption resulting from chronic pancreatitis, inflammatory bowel disease, celiac disease, cystic fibrosis, Whipple’s disease, radiation enteritis, bariatric surgery Metabolic factors: Chronic renal insufficiency (from decreased…

Measurement Surgery recommended in all who meet the following guideline Age <50 years old Bone mineral density T-score <−2.5 at any site and/or prior fragility fracture Creatinine clearance (calculated) <60…