Cancer Immunology
Cancer Immunology CANCER IMMUNOBIOLOGY Gabriela Soriano Hobbs Alexander M. Lesokhin Cancer Immunology Basics The immune system plays an important role in CA surveillance; Rx that modulate & amplify the immune…
Molecular Diagnostics
Molecular Diagnostics SEQUENCING Chung-Han Lee Classic Sanger Sequencing Developed in 1977 by Frederick Sanger & colleagues Required reagents DNA template (what you want to seq) DNA primer (known seq) dNTPs…
Cancer Biology
Cancer Biology CANCER HALLMARKS & STEM CELLS Alexander Drilon Hallmarks of Cancer CAs share a set of common distinctive & complementary capabilities that enable tumor growth & met dissemination (Cell…
Radiation Oncology
Radiation Oncology BASIC RADIATION BIOLOGY AND PHYSICS Gaorav P. Gupta Barry S. Rosenstein Definitions Ionizing Radiation (IR): Photons that have adequate energy to eject orbital electrons from target molecules X-rays:…
Clinical Research Methods
Clinical Research Methods PHASE I CLINICAL TRIALS Connie Lee Batlevi David R. Spriggs Phase 0 Trials Proof of concept trials designed to be first in human (Nat Rev Cancer 2007;7:131)…
General Oncology
General Oncology CANCER EPIDEMIOLOGY Anita Kumar Victoria Blinder Cancer Epidemiology Research Methods Epidemiology: Study of distribution, determinants, & outcomes of cancer at a population level; applies public health or policy…
Chemotherapy of Multiple Myeloma
Chemotherapy of Multiple Myeloma Robert A. Kyle S. Vincent Rajkumar Francis Buadi Multiple myeloma (MM) is a plasma cell malignancy that accounts for slightly >10% of the hematologic malignancies. The…
Management of Myeloproliferative Disorders and Chronic Myeloid Leukemia
Management of Myeloproliferative Disorders and Chronic Myeloid Leukemia Ayalew Tefferi The myeloproliferative neoplasms (MPN) are considered separate from the myelodysplastic syndromes (MDS) and are further classified into classic and nonclassic…
Myelodysplastic Syndromes
Myelodysplastic Syndromes Christopher R. Cogle Rami S. Komrokji Alan F. List The myelodysplastic syndromes (MDS) comprise a spectrum of neoplastic hematopoietic stem cell disorders that share the features of ineffective…
Acute Myeloid Leukemia
Acute Myeloid Leukemia Radwan F. Khozouz Carl E. Freter Acute myeloid leukemia (AML) accounts for 90% of acute leukemias diagnosed in adults, while comprising only a minority (15% to 20%)…
