Cell Biology, Protein Processing, and Cell Signaling Randal J. Kaufman Laura Popolo In order to perform their multiple functions, eukaryotic cells have evolved an internal structural organization that consists of…
Coagulation Enzymology Sriram Krishnaswamy THE CONTEXT Blood coagulation is initiated by the exposure of tissue factor to flowing blood following vascular damage.1,2 A series of highly specific proteolytic activation steps…
Molecular and Clinical Genetics Lesley Everett Karl Desch David Ginsburg Keeping up to date with the remarkable progress in human genetics and the rapidly changing genomic laboratory toolbox poses a…
Molecular Evolution of the Vertebrate Blood Coagulation System Marianne A. Grant William C. Aird Most multicellular organisms have evolved hemostatic mechanisms to prevent the loss of fluid and promote blood…
The Field of Hemostasis and Thrombosis: Selected Translational Achievements Victor J. Marder William C. Aird Joel S. Bennett Sam Schulman Gilbert C. White II INTRODUCTION As with any field of…
General Principles and Management Bruce J. Davidson Kenneth A. Newkirk Kenneth D. Burman THYROID CANCER Introduction Epidemiology—Increasing Incidence of Thyroid Cancer. According to cancer statistics, there has been a substantial…
Systemic Targeted Therapy for Recurrent and Metastatic Head and Neck Squamous Cell Cancer Matthew G. Fury David G. Pfister This chapter reviews chemotherapy options for patients with recurrent and metastatic…
General Principles and Management Brian O’Sullivan Abha Gupta Patrick Gullane INTRODUCTION Sarcomas are rare malignancies of mesodermal origin. The annual incidence is <10,000 per year in North America. Fifteen percent…
Radiologic Imaging Concerns Jeffrey A. Bennett Almost all varieties of sarcoma occur in the head and neck, and virtually all warrant imaging prior to treatment. When the tumor is small,…
Radiologic Imaging Concerns Jeffrey A. Bennett Thyroid nodules are detected frequently on physical examination and are found even more commonly on imaging studies of the neck, including computed tomography (CT),…
