Oncogenic Role of Hepatitis B Virus
Fig. 1 The hepatitis B virus genome and the covalently closed circular DNA (cccDNA). The viral genome (left panel) is made of two linear DNA strands maintained in circular configuration by…
Biology of Human Herpesvirus 8: Novel Functions and Virus–Host Interactions Implicated in Viral Pathogenesis and Replication
Fig. 1 ER-localized interactions and activities of vIL-6 in latently infected PEL cells. In the context of PEL latency, vIL-6 is expressed at low but functional levels and is largely sequestered…
and Leukemogenesis: Virus–Cell Interactions in the Development of Adult T-Cell Leukemia
Fig. 1 A multireceptor model for HTLV-1 entry. HSPG = heparan sulfate proteoglycans; SU = the subunit of HTLV-1 envelope glycoprotein; NRP-1 = neuropilin-1; GLUT-1 = glucose transporter 1; CTD = C-terminal domain; RBD = receptor-binding domain; PRR = proline-rich region. This drawing is modified…
of Virus Infection and Human Cancer
Virus Cancer sites with sufficient evidence Cancer sites with limited evidence Epstein–Barr virus (EBV) Nasopharyngeal carcinoma, Burkitt’s lymphoma, immune suppression-related non-Hodgkin lymphoma, extranodal NK/T cell lymphoma (nasal type), Hodgkin’s lymphoma…
Oncogenic Role of Hepatitis C Virus
Fig. 1 The structure of hepatitis C virus genome. The HCV genome RNA encodes a polyprotein of 3,010 a.a., which is processed into structural and non-structural proteins by the cellular or…
of Hepatitis B Virus Infection and Liver Cancer
Risk factors High risk/low risk References Viral factors 1. HBsAg Positive/negative = 66/1 Beasley et al. (1981) 2. HBeAg in HBsAg-positive persons Positive/negative = 60/10 Yang et al. (2002) 3. HBV DNA level…
of HPV Infection and Related Cancer Through Vaccination
Type Advantage Disadvantage Developmental stage References Live vector-based Highly immunogenic customizable Vector-specific neutralizing antibodies or pre-existing vector-specific immunity, safety concerns, flu-like adverse effects ADXS11-001 in phase II Trial Maciag et…
Treatment and Cancer Control
Virus a Cancer type b Antiviral therapy c HBV HCC Interferons (Interferon-α and pegylated interferon-α2a) Nucleos(t)ide analogues (Lamivudine, adefovir, entecavir, telbivudine, and tenofovir) HCV HCC Peglyated interferon plus ribavirin …
of Human T-Cell Lymphotropic Virus Type 1 Infection and Adult T-Cell Leukemia/Lymphoma
Year The number of blood transfusion donor The number of HTLV-1 carrier % 1999 98,644 2,751 2.79 2000 91,456 1,368 1.50 2001 92,281 1,048 1.14 2002 89,458 827 0.92 2003…
and Treatment for Epstein–Barr Virus Infection and Related Cancers
Incidence (%) Type of organ Children Adults or all Liver 4–15 1.6–5 Kidney 1–10 0.5–1 Heart–lung 6–20 1.9–10 Intestine 12 – Bone marrow or stem cells – 0.5–8 Gulley…
