Senescence, Apoptosis, and Cancer

Sep 20, 2017 by in ONCOLOGY Comments Off on Senescence, Apoptosis, and Cancer

Fig. 10.1 In cell culture systems, cellular senescence is described as a decrease in proliferative capacity and eventual cessation of proliferation with increasing number of population doublings (PDs). This property…

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Cancer Drug Discovery and Anticancer Drug Development

Sep 20, 2017 by in ONCOLOGY Comments Off on Cancer Drug Discovery and Anticancer Drug Development

Fig. 36.1 Schematic representation of target-based drug discovery and development process . Drug discovery process typically begins with the identification and the validation of the target in vitro and in…

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Molecular Detection and Diagnosis of Cancer

Sep 20, 2017 by in ONCOLOGY Comments Off on Molecular Detection and Diagnosis of Cancer

Fig. 41.1 Activating mutations in K-Ras occurring early on during pancreatic cancer development lead to higher proliferating rates of affected cells. While this may trigger the cell surveillance system that…

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Cancer Cytogenetics

Sep 20, 2017 by in ONCOLOGY Comments Off on Cancer Cytogenetics

Fig. 4.1 Early chromosome analysis and molecular cytogenetics. (a) Photograph of Theodor Boveri (1862–1915). Boveri was a professor of zoology in Würzburg, Germany. Combining his theory that chromosomes carry genetic…

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Epigenetic Mechanisms in Cancer Development

Sep 20, 2017 by in ONCOLOGY Comments Off on Epigenetic Mechanisms in Cancer Development

Fig. 16.1 Graphical display of the most common epigenetic changes in CpG islands of tumor suppressor genes and DNA repeats in normal and cancer cells. 16.3 Technical Approaches to Detect…

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Therapeutic Agents That Inhibit Angiogenesis

Sep 20, 2017 by in ONCOLOGY Comments Off on Therapeutic Agents That Inhibit Angiogenesis

Date approved Drug Place Disease May 2003 Bortezomib USA (FDA) Multiple myeloma December 2003 Thalidomide Australia Multiple myeloma February 2004 Bevacizumaba USA (FDA) Colorectal cancer November 2004 Erlotinib USA (FDA)…

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