Oncohema Key

Fig. 1 Normal thyroid gland with immunohistochemically demonstrated C cells. The predominantly disperse distributed C cells are located intrafollicular (calcitonin immunohistochemistry, ×200) Some decades later, electron microscopic studies supported the observation…

Fig. 1 Longitudinal US section of the left thyroid lobe, showing a sharply but irregularly delineated, hypoechogenic medullary thyroid carcinoma (arrows) with internal microcalcifications (open arrow) Fig. 2 Transverse (a) and longitudinal…

Fig. 1 Role of ATF4 in regulation of apoptosis. Activation of RET by ligand activation or mutation results in its translocation to the nucleus, where it reduces transcription and promotes ubiquitination…

Fig. 1 RET receptor activation. Shown is a schematic figure outlining the basic structural organization of the transmembrane receptor tyrosine kinase RET and the pathway to its activation. One of the…

Fig. 1 Histology of pheochromocytoma. a Pheochromocytoma demonstrates a typical nested architecture (H&E, original magnification 100×). b At high power, the pheochromocytoma cells demonstrate a granular amphophilic cytoplasm and moderate nuclear…

Period Milestone Mid-nineteenth century Case reports on medullary thyroid cancer (MTC) as a rare tumor entity among young adults within the spectrum of thyroid cancers (Gurlt 1861; Billroth 1869; Wölfer…

Variety of MTC Incidence Age at clinical diagnosis Associated endocrinopathies Sporadic MTC 75 5th decade None Hereditary MTC 25   – MEN2A –23 3rd decade Pheochromocytoma Parathyroid adenoma Cutaneous lichen amyloidosis…